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A Polygenic Predictor of Baseline QTc is Associated With Sotalol-Induced QT Prolongation.

作者信息

Lancaster Megan C, Davogustto Giovanni, Prifti Edi, Perret Claire, Funck-Brentano Christian, Roden Dan M, Salem Joe-Elie

机构信息

Department of Medicine, Division of Cardiovascular Medicine (M.C.L., G.D., J.-E.S., D.M.R.), Vanderbilt University Medical Center, Nashville, TN.

IRD, Sorbonne Université, Unité de Modélisation Mathématique et Informatique des Systèmes Complexes, UMMISCO, Bondy, France (E.P.).

出版信息

Circulation. 2024 Dec 10;150(24):1984-1986. doi: 10.1161/CIRCULATIONAHA.124.070337. Epub 2024 Dec 9.

DOI:10.1161/CIRCULATIONAHA.124.070337
PMID:39652646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12100608/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93bf/12100608/fd12d6ec39ee/nihms-2031566-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93bf/12100608/fd12d6ec39ee/nihms-2031566-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93bf/12100608/fd12d6ec39ee/nihms-2031566-f0001.jpg

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本文引用的文献

1
Monogenic and Polygenic Contributions to QTc Prolongation in the Population.单基因和多基因对人群 QTc 延长的贡献。
Circulation. 2022 May 17;145(20):1524-1533. doi: 10.1161/CIRCULATIONAHA.121.057261. Epub 2022 Apr 7.
2
Pharmacogenomics.药物基因组学。
Lancet. 2019 Aug 10;394(10197):521-532. doi: 10.1016/S0140-6736(19)31276-0. Epub 2019 Aug 5.
3
GENomE wide analysis of sotalol-induced IKr inhibition during ventricular REPOLarization, "GENEREPOL study": Lack of common variants with large effect sizes.索他洛尔诱导心室复极期间 IKr 抑制的全基因组分析，“GENEREPOL 研究”：缺乏具有大效应量的常见变异体
PLoS One. 2017 Aug 11;12(8):e0181875. doi: 10.1371/journal.pone.0181875. eCollection 2017.
4
Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study.常见基因变异风险评分与药物诱导的QT间期延长及尖端扭转型室速风险相关：一项初步研究。
Circulation. 2017 Apr 4;135(14):1300-1310. doi: 10.1161/CIRCULATIONAHA.116.023980. Epub 2017 Feb 17.
5
Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation.医院环境中尖端扭转型室速的预防：美国心脏协会和美国心脏病学基金会的科学声明
J Am Coll Cardiol. 2010 Mar 2;55(9):934-47. doi: 10.1016/j.jacc.2010.01.001.