Jia Ying, Zhang Ziming, Gao Shangjie, Jiang Fengli, Wang Yuhao, Su Xueshang, Zhuang Jun, Li Jingjing, Hu Jintian, Zhan Sien
From the Department of Ultrasound.
Department of Ear Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing.
Ann Plast Surg. 2025 Feb 1;94(2):217-221. doi: 10.1097/SAP.0000000000004159. Epub 2024 Dec 5.
Situs inversus is a congenital malformation that occurs in one or multiple organs simultaneously and can be accompanied by malformations in other body parts. We analyzed the prevalence and phenotype of patients with situs inversus and comorbidities associated with other plastic surgery-related malformations to enhance the knowledge of its related disorders and facilitate treatment.
We recruited patients with situs inversus who were seen at our institution from February 2015 to July 2023. They underwent ultrasound and physical examinations to investigate deformity in other body parts. Fisher's exact test was used to analyze the laterality between hemifacial microsomia and situs inversus type.
All 14 patients with situs inversus had plastic surgery-related malformations-three congenital and three developmental. Nine (65%) patients had hemifacial microsomia (right side, n = 8; bilateral, n = 1). The laterality of hemifacial microsomia was associated with the situs inversus type, with a significant difference ( P < 0.05), and hemifacial microsomia occurred ipsilaterally in patients with right-sided hearts.
Early situs inversus diagnosis is clinically important for patients and plastic surgeons. Further studies on anomalies associated with situs inversus will improve our understanding of their etiology.
内脏反位是一种先天性畸形，可同时发生在一个或多个器官，并可能伴有身体其他部位的畸形。我们分析了内脏反位患者的患病率、表型以及与其他整形手术相关畸形合并存在的情况，以增进对其相关疾病的了解并促进治疗。
我们招募了2015年2月至2023年7月期间在我院就诊的内脏反位患者。他们接受了超声和体格检查，以调查身体其他部位的畸形情况。采用Fisher精确检验分析半侧颜面短小畸形与内脏反位类型之间的左右侧关系。
所有14例内脏反位患者均有与整形手术相关的畸形——3例先天性畸形和3例发育性畸形。9例（65%）患者患有半侧颜面短小畸形（右侧，n = 8；双侧，n = 1）。半侧颜面短小畸形的左右侧与内脏反位类型相关，差异有统计学意义（P < 0.05），且右侧心脏患者的半侧颜面短小畸形发生在同侧。
早期诊断内脏反位对患者和整形外科医生具有重要的临床意义。对与内脏反位相关异常的进一步研究将增进我们对其病因的理解。
