Di Guardo Antonio, Balampanos Charalampos G, Gargano Luca, Giordano Domenico, Capalbo Alessandro, Persechino Flavia, Persechino Severino
Department of Dermatology, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Department of Dermatology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Dermatol Pract Concept. 2024 Oct 30;14(4):e2024237. doi: 10.5826/dpc.1404a237.
Cutaneous chondroid syringoma (CS) is a rare benign mixed skin tumor originating from sweat glands. Despite its rarity, accurate diagnosis and management are crucial due to its potential for malignant transformation.
This study aimed to provide comprehensive insights into the main features of cutaneous CS, encompassing its epidemiology, clinical presentation, and particularly, dermoscopic findings.
A systematic review was conducted to identify relevant literature on CS up to November 2023. Data extraction included clinical and histopathological characteristics from case reports and small case series.
The systematic review identified 347 unique CS cases, predominantly benign. Clinical features included a predilection for the head and neck region, with variations in morphology observed. Dermoscopic patterns, although limited, revealed recurrent features aiding diagnosis. Malignant CS cases constituted a notable subset, exhibiting distinct clinical and histopathological features.
Cutaneous chondroid syringoma presents with characteristic clinical and histopathological features, necessitating comprehensive diagnostic approaches. Dermoscopy emerges as a valuable tool, although further research is needed to establish definitive patterns. Treatment primarily involves wide local excision, with collaboration among clinicians essential for optimal management. Future studies are warranted to address existing knowledge gaps and enhance understanding of this rare skin neoplasm.
皮肤软骨样汗腺螺旋瘤（CS）是一种罕见的起源于汗腺的良性混合性皮肤肿瘤。尽管其罕见，但由于其有恶变的可能，准确的诊断和管理至关重要。
本研究旨在全面深入了解皮肤CS的主要特征，包括其流行病学、临床表现，特别是皮肤镜检查结果。
进行了一项系统综述，以识别截至2023年11月关于CS的相关文献。数据提取包括病例报告和小病例系列中的临床和组织病理学特征。
系统综述确定了347例独特的CS病例，主要为良性。临床特征包括好发于头颈部区域，观察到形态各异。皮肤镜模式虽然有限，但显示出有助于诊断的反复出现的特征。恶性CS病例构成了一个显著的亚组，表现出独特的临床和组织病理学特征。
皮肤软骨样汗腺螺旋瘤具有特征性的临床和组织病理学特征，需要综合诊断方法。皮肤镜检查成为一种有价值的工具，尽管需要进一步研究以确定明确的模式。治疗主要包括广泛局部切除，临床医生之间的合作对于最佳管理至关重要。未来的研究有必要填补现有知识空白并增强对这种罕见皮肤肿瘤的理解。
