Dick J E, Wright J A
FEBS Lett. 1985 Jan 1;179(1):21-4. doi: 10.1016/0014-5793(85)80182-4.
Previous studies have indicated that ribonucleotide reductase may participate in a mechanism of cellular senescence, which involves modifications in deoxyribonucleotide pools, the products of the reductase reaction. Since very little information about the levels of these pools in senescing cells is currently available, an analysis of deoxyribonucleotide levels was carried out in young, old and very old normal human diploid fibroblasts, as well as in a variant human fibroblast strain with an altered replicative life span. These studies indicated that there are marked age-related perturbations in these pools which imply that they may be fundamentally important in a process determining the nonproliferative or senescent state.
先前的研究表明，核糖核苷酸还原酶可能参与细胞衰老机制，该机制涉及脱氧核苷酸池（还原酶反应的产物）的修饰。由于目前关于衰老细胞中这些池水平的信息非常少，因此对年轻、年老和非常年老的正常人二倍体成纤维细胞以及具有改变的复制寿命的变异人成纤维细胞系进行了脱氧核苷酸水平分析。这些研究表明，这些池中存在明显的与年龄相关的扰动，这意味着它们在决定非增殖或衰老状态的过程中可能至关重要。
