Wang X B, Wang R C, Tu Q, Zhang W, Li Z D
Department of Medical Imaging, Zibo Municipal Hospital, Zibo255400, China.
Department of Pathology, Zibo Municipal Hospital, Zibo255400, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2024 Dec 12;47(12):1159-1162. doi: 10.3760/cma.j.cn112147-20240113-00027.
Pulmonary nodular lymphoid hyperplasia (PNLH) is a rare pulmonary lymphoproliferative disease characterized by the absence of specific clinical and imaging features. Consequently, diagnosis relies heavily on postoperative pathological examination, which often leads to preoperative misdiagnosis. Here, we report an atypical case of PNLH in a 57-year-old female patient who was admitted to hospital after a pulmonary nodule was discovered during a routine physical examination two days earlier. Chest CT scan revealed a mixed ground-glass nodule in the apicoposterior segment of the left upper lobe, with lobulation and spiculation. These imaging findings initially suggested a diagnosis of pulmonary malignancy. However, pathological examination and IgH gene rearrangement analysis of the resected tissue ultimately confirmed the diagnosis of PNLH.
肺结节样淋巴组织增生(PNLH)是一种罕见的肺淋巴增殖性疾病,其特点是缺乏特异性的临床和影像学特征。因此,诊断在很大程度上依赖于术后病理检查,这常常导致术前误诊。在此,我们报告一例57岁女性患者的非典型PNLH病例,该患者在两天前的常规体检中发现肺部结节后入院。胸部CT扫描显示左肺上叶尖后段有一个混合性磨玻璃结节,伴有分叶和毛刺。这些影像学表现最初提示为肺恶性肿瘤。然而,对切除组织进行的病理检查和IgH基因重排分析最终确诊为PNLH。