Zhang Yihan, Li Yuting, Fang Bowen, Du Yi, Peng Pai
School of Life Sciences, Anhui Medical University, Hefei, Anhui, 230032, China.
Chembiochem. 2025 Feb 3;26(5):e202400810. doi: 10.1002/cbic.202400810. Epub 2024 Dec 17.
As emerging biomaterials, framework nucleic acids (FNAs) have recently demonstrated great potential in the biomedical field due to their high programmability, biocompatibility, unique structural diversity, and precise molecular design capabilities. This review focuses on the applications of FNAs in cellular sensing and disease treatment. First, we systematically introduce the applications of FNAs in cellular sensing, including their precise recognition and response to the extracellular tumor microenvironment, cell membrane proteins, and intracellular biomarkers. Subsequently, we review the potential of FNAs in disease treatment, covering their applications and development in drug delivery, regulation of cell behavior, and immunomodulation. We also discuss the limitations and potential role of FNAs in personalized medicine, precision diagnostics, and advanced therapies. The broad application of FNAs is expected to drive significant breakthroughs in future biomedical technological innovations and clinical translation.
作为新兴的生物材料，骨架核酸（FNA）由于其高度的可编程性、生物相容性、独特的结构多样性和精确的分子设计能力，近年来在生物医学领域展现出了巨大的潜力。本综述聚焦于FNA在细胞传感和疾病治疗中的应用。首先，我们系统地介绍了FNA在细胞传感中的应用，包括其对细胞外肿瘤微环境、细胞膜蛋白和细胞内生物标志物的精确识别和响应。随后，我们综述了FNA在疾病治疗中的潜力，涵盖其在药物递送、细胞行为调控和免疫调节方面的应用和发展。我们还讨论了FNA在个性化医学、精准诊断和先进疗法中的局限性及潜在作用。FNA的广泛应用有望推动未来生物医学技术创新和临床转化取得重大突破。
