口腔黏膜下纤维化患者低强度激光治疗与病灶内注射的比较评估：一项半随机试验
Comparative Evaluation of Low-level Laser Therapy and Intralesional Injection in OSMF Patients: A Quasi-randomized Trial.
作者信息
Pattnayak Anwesha, Das Asutosh, Rana Priyanka, Raghunandanan Sunil, Panicker Prasanth, Kumar P Manoj
机构信息
Department of Oral and Maxillofacial Surgery, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India, Phone: +91 7077027413, e-mail:
Department of Oral and Maxillofacial Surgery, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India.
出版信息
J Contemp Dent Pract. 2024 Aug 1;25(8):745-750. doi: 10.5005/jp-journals-10024-3703.
AIM
The aim of the present study was to compare the effectiveness of low-level laser therapy and intralesional injection in oral submucous fibrosis (OSMF) patients.
MATERIALS AND METHODS
The present study comprised of 52 grade II OSMF patients aged between 20 and 60 years. A pretreatment assessment was done for each patients. And 52 patients were divided into two groups (26 patients in each group). Group I received intralesional injections, and group II received low-level laser therapy (LLLT). The intralesional injection group received 0.5 mL 1500 I.U. Hyaluronidase with 2 mL dexamethasone biweekly for a month. The LLLT group underwent sessions of 0.1 watt laser only once for 3 cycles, each lasting 1 minute with 5-minute intervals. Evaluation of overall accessibility, burning sensation and mouth opening was done for both the treatment modalities on 0, 3rd, 7th and 15th day. All data were recorded and statistically analyzed.
RESULTS
On comparison of burning sensation in intralesional Injection group, at baseline, the mean value was 4.00 ± 0.84 and it reduced to 1.19 ± 0.40 while in LLLT group from 4.15 ± 0.96 at baseline, it reduced to 2.65 ± 0.68 at the end of 15 days, respectively. On comparison of mouth opening in intralesional Injection group, at baseline, the mean value was 21.73 ± 1.56 and it increased to 32.53 ± 0.97 while in LLLT group from 22.70 ± 2.17 at baseline, it increased to 24.50 ± 1.31 at the end of 15 days, respectively. There was a statistically significant difference found between the two groups.
CONCLUSION
The present study concluded that intralesional injections are more effective in treating grade II OSMF compared with LLLT.
CLINICAL SIGNIFICANCE
Several different treatment options are available to treat OSMF, including medical approaches, surgical management, and physiotherapy. One of the important therapeutic modalities is intralesional injection therapy with corticosteroids as they reduce inflammation and immunosuppression while hyaluronidase increases tissue permeability. How to cite this article: Pattnayak A, Das A, Rana P, et al. Comparative Evaluation of Low-level Laser Therapy and Intralesional Injection in OSMF Patients: A Quasi-randomized Trial. J Contemp Dent Pract 2024;25(8):745-750.
目的
本研究旨在比较低强度激光治疗和病灶内注射对口腔黏膜下纤维化（OSMF）患者的疗效。
材料与方法
本研究纳入了52例年龄在20至60岁之间的II级OSMF患者。对每位患者进行了治疗前评估。52例患者被分为两组（每组26例）。第一组接受病灶内注射，第二组接受低强度激光治疗（LLLT）。病灶内注射组每两周接受一次0.5 mL含1500国际单位透明质酸酶的2 mL地塞米松注射，共一个月。LLLT组仅接受0.1瓦激光照射，每次照射1分钟，间隔5分钟，共进行3个周期。在第0、3、7和15天对两种治疗方式的总体可及性、烧灼感和张口度进行评估。记录所有数据并进行统计学分析。
结果
比较病灶内注射组的烧灼感，基线时平均值为4.00±0.84，15天后降至1.19±0.40；而LLLT组基线时为4.15±0.96，15天后降至2.65±0.68。比较病灶内注射组的张口度，基线时平均值为21.73±1.56，15天后增至32.53±0.97；而LLLT组基线时为22.70±2.17，15天后增至24.50±1.31。两组之间存在统计学显著差异。
结论
本研究得出结论，与LLLT相比，病灶内注射治疗II级OSMF更有效。
临床意义
治疗OSMF有几种不同的治疗选择，包括药物治疗、手术治疗和物理治疗。重要的治疗方式之一是使用皮质类固醇进行病灶内注射治疗，因为它们可减轻炎症和免疫抑制，而透明质酸酶可增加组织通透性。如何引用本文：Pattnayak A, Das A, Rana P,等。OSMF患者低强度激光治疗与病灶内注射的比较评估：一项半随机试验。《当代牙科实践杂志》2024；25(8):745 - 750。
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