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引用本文的文献

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Baseline Neurocognitive Functioning Among Children Treated for Acute Lymphoblastic Leukemia (ALL): Dana Farber Cancer Institute ALL Consortium Study 16-001.接受急性淋巴细胞白血病（ALL）治疗的儿童的基线神经认知功能：达纳-法伯癌症研究所ALL联盟研究16-001。
Pediatr Blood Cancer. 2025 Aug;72(8):e31767. doi: 10.1002/pbc.31767. Epub 2025 May 13.

本文引用的文献

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Neurocognitive outcome and associated factors in long-term, adult survivors of childhood acute lymphoblastic leukemia, treated without cranial radiation therapy.儿童期急性淋巴细胞白血病长期幸存者（未经颅放射治疗）的神经认知结局及其相关因素。
J Int Neuropsychol Soc. 2024 Jul;30(6):523-532. doi: 10.1017/S1355617724000080. Epub 2024 Mar 11.
2
Cognitive Impairment in Survivors of Pediatric Acute Lymphoblastic Leukemia Treated With Chemotherapy Only.仅接受化疗的小儿急性淋巴细胞白血病幸存者的认知障碍
J Clin Oncol. 2021 Jun 1;39(16):1705-1717. doi: 10.1200/JCO.20.02322. Epub 2021 Apr 22.
3
Cognitive Risk in Survivors of Pediatric Brain Tumors.儿童脑肿瘤幸存者的认知风险
J Clin Oncol. 2021 Jun 1;39(16):1718-1726. doi: 10.1200/JCO.20.02338. Epub 2021 Apr 22.
4
Cognitive function of children and adolescent survivors of acute lymphoblastic leukemia: A meta-analysis.急性淋巴细胞白血病儿童及青少年幸存者的认知功能：一项荟萃分析。
Oncol Lett. 2021 Apr;21(4):262. doi: 10.3892/ol.2021.12523. Epub 2021 Feb 5.
5
Monitoring neurocognitive functioning in childhood cancer survivors: evaluation of CogState computerized assessment and the Behavior Rating Inventory of Executive Function (BRIEF).监测儿童癌症幸存者的神经认知功能：CogState 计算机评估和行为评估量表（BRIEF）的评估。
BMC Psychol. 2019 May 2;7(1):26. doi: 10.1186/s40359-019-0302-3.
6
Computerized assessment of cognitive impairment among children undergoing radiation therapy for medulloblastoma.计算机评估接受髓母细胞瘤放射治疗的儿童的认知障碍。
J Neurooncol. 2019 Jan;141(2):403-411. doi: 10.1007/s11060-018-03046-2. Epub 2018 Nov 22.
7
Clinicopathological Study of Pediatric Posterior Fossa Tumors.小儿后颅窝肿瘤的临床病理研究
J Pediatr Neurosci. 2017 Jul-Sep;12(3):245-250. doi: 10.4103/jpn.JPN_113_16.
8
Characterizing neurocognitive late effects in childhood leukemia survivors using a combination of neuropsychological and cognitive neuroscience measures.使用神经心理学和认知神经科学测量方法相结合的方式来表征儿童白血病幸存者的神经认知迟发效应。
Child Neuropsychol. 2018 Nov;24(8):999-1014. doi: 10.1080/09297049.2017.1386170. Epub 2017 Oct 10.
9
Monitoring and Assessment of Neuropsychological Outcomes as a Standard of Care in Pediatric Oncology.作为儿科肿瘤学护理标准的神经心理学结果监测与评估
Pediatr Blood Cancer. 2015 Dec;62 Suppl 5:S460-513. doi: 10.1002/pbc.25749.
10
SEER update of incidence and trends in pediatric malignancies: acute lymphoblastic leukemia.监测、流行病学和最终结果（SEER）项目关于儿童恶性肿瘤发病率及趋势的更新：急性淋巴细胞白血病
Med Pediatr Oncol. 2002 Dec;39(6):554-7; discussion 552-3. doi: 10.1002/mpo.10161.

在急性淋巴细胞白血病治疗期间对3岁患者使用简短神经认知测试组的可行性

Feasibility of Utilizing a Brief Neurocognitive Battery in 3-Year-Old Patients During Treatment for Acute Lymphoblastic Leukemia.

作者信息

Ramjan Sameera, Cole Peter D, Blair-Thies Melanie, Silverman Lewis B, Fredrickson Amy, Schembri Adrian, Welch Jennifer J Greene, Kahn Justine, Kelly Kara M, Tran Thai-Hoa, Michon Bruno, Gennarini Lisa, Sands Stephen A

机构信息

Department of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Rutgers Cancer Institute, New Brunswick, New Jersey, USA.

出版信息

Pediatr Blood Cancer. 2025 Mar;72(3):e31469. doi: 10.1002/pbc.31469. Epub 2024 Dec 9.

DOI:10.1002/pbc.31469
PMID:39654084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11759646/
Abstract

Treatment of acute lymphoblastic leukemia (ALL) is associated with neurocognitive deficits in young children. While computerized measures have been utilized in pediatric oncology research, they exclude patients below the age of 4 years. Patients enrolled on "Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents" were offered participation in an optional neurocognitive study. Three-year old patients did not differ from 4-year-old patients in their ability to perform or complete the tests. Including patients diagnosed at age 3 will serve to improve our understanding of at-risk patients and their neurocognitive trajectory both during and after treatment.

摘要

急性淋巴细胞白血病（ALL）的治疗与幼儿的神经认知缺陷有关。虽然计算机化测量已用于儿科肿瘤学研究，但这些测量方法将4岁以下的患者排除在外。参与“儿童和青少年新诊断急性淋巴细胞白血病的治疗”的患者可选择参加一项神经认知研究。3岁患者在执行或完成测试的能力方面与4岁患者没有差异。纳入3岁时被诊断出的患者将有助于提高我们对高危患者及其在治疗期间和治疗后的神经认知轨迹的理解。