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肾激光碎石术后由鹑鸡肠球菌引起感染性心内膜炎的罕见病例报告

A rare case report of infective endocarditis caused by Enterococcus gallinarum following renal laser lithotripsy.

作者信息

Wang Ruoxin, Lv Meng, Fu Liang, Zhao Jinlong, Ni Yinkai, Li Tianyu, Chen Zonghui, Li Feng

机构信息

Department of Cardiovascular Surgery, The Shanghai Sixth People's Hospital, Shanghai, China.

Genoxor Medical Science and Technology Inc., Shanghai, China.

出版信息

Medicine (Baltimore). 2024 Dec 6;103(49):e40802. doi: 10.1097/MD.0000000000040802.

Abstract

RATIONALE

Enterococcus gallinarum is a part of the normal fecal microbiota in the general population and animals, and is rarely isolated in clinical specimens. Due to the increasing use of immunosuppressants, invasive treatments, and overuse of antibiotics, infections caused by enterococci are gradually increasing.

PATIENT CONCERNS

A 48-year-old man was admitted to our hospital due to a persistent fever for 1 month after renal laser lithotripsy.

DIAGNOSES

The cardiac ultrasound showed a mass on the mitral valve leaflet of the left atrium. The metagenomic next-generation sequencing test results of blood and vegetation were positive, reporting a large number of characteristic reads of E. gallinarum. The patient was diagnosed with infective endocarditis.

INTERVENTIONS

Mechanical mitral valve replacement was performed, and daptomycin was administered during the perioperative period.

OUTCOMES

After 4 weeks of antibiotic treatment, the patient's inflammatory indexes were normal, and no abnormalities such as fever were found. Blood culture and metagenomic next-generation sequencing test results were negative. The patient was then discharged from the hospital.

LESSONS

This case emphasizes the possibility of E. gallinarum developing severe invasive infections after kidney surgery. Clinical doctors should strengthen their understanding of this type of bacteria, understand their sensitive characteristics and treatment principles.

摘要

理论依据

鹑鸡肠球菌是普通人群和动物正常粪便微生物群的一部分,在临床标本中很少分离到。由于免疫抑制剂的使用增加、侵入性治疗以及抗生素的过度使用,肠球菌引起的感染逐渐增多。

患者情况

一名48岁男性在肾激光碎石术后持续发热1个月后入住我院。

诊断

心脏超声显示左心房二尖瓣叶有一个肿块。血液和赘生物的宏基因组下一代测序检测结果呈阳性,报告有大量鹑鸡肠球菌的特征性读数。该患者被诊断为感染性心内膜炎。

干预措施

进行了二尖瓣机械瓣置换术,并在围手术期给予达托霉素。

结果

经过4周的抗生素治疗,患者的炎症指标恢复正常,未发现发热等异常情况。血培养和宏基因组下一代测序检测结果均为阴性。患者随后出院。

经验教训

该病例强调了鹑鸡肠球菌在肾脏手术后发生严重侵袭性感染的可能性。临床医生应加强对这类细菌的认识,了解其敏感特性和治疗原则。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a83/11630988/3131de6e07ab/medi-103-e40802-g001.jpg

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