Lackey Taylor G, Allen Avery, McCabe Nevan, Clary Matthew, Green Katherine K, Fink Daniel S
Department of Otolaryngology-Head and Neck Surgery, University of Colorado Denver, Aurora, CO, USA.
Ann Otol Rhinol Laryngol. 2025 Apr;134(4):266-273. doi: 10.1177/00034894241305880. Epub 2024 Dec 9.
To investigate the association between subglottic stenosis (SGS) and obstructive sleep apnea (OSA).
This is a cross-sectional pilot cohort study conducted at a single tertiary academic center from 2022 to 2023. Subjects with non-traumatic SGS were recruited for enrollment. All subjects completed a peak expiratory flow (PEF) measurement, validated sleep questionnaires: Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI), and a 1-night home sleep test (HST). Demographic data were summarized. Prevalence was calculated and descriptively compared to a matched population. Partial correlation analysis evaluated the relationship of PEF% and Meyer-Cotton grading, in addition to PEF% and apnea-hypopnea index (AHI). Sleep quality was compared in subjects with and without OSA via a Mann-Whitney test.
Twenty subjects participated; all were Caucasian females with a mean age of 48.4 (10.4) years and a body mass index (BMI) of 24.1 (3.8). The majority (80%) had idiopathic SGS, and a mean PEF 288 (71) L/min. OSA was present in 40% of subjects, of which 15% had moderate OSA. PEF% did not correlate to AHI ( > .05). Poor sleep quality (PSQI ≥ 5) was present in 70% of subjects and 20% had excessive daytime sleepiness (ESS > 9). PSQI and ESS did not differ between subjects with and without OSA ( > .05).
OSA prevalence is elevated in a cohort of subjects with SGS. Further study of airway dilation's impact on OSA is necessary. Screening and surveillance for OSA in patients with subglottic stenosis may need to be considered based on this study's findings.Level of Evidence: Level 3.
探讨声门下狭窄（SGS）与阻塞性睡眠呼吸暂停（OSA）之间的关联。
这是一项于2022年至2023年在单一三级学术中心进行的横断面试点队列研究。招募患有非创伤性SGS的受试者入组。所有受试者均完成了呼气峰值流速（PEF）测量、经过验证的睡眠问卷：爱泼华嗜睡量表（ESS）和匹兹堡睡眠质量指数（PSQI），以及一晚的家庭睡眠测试（HST）。汇总人口统计学数据。计算患病率并与匹配人群进行描述性比较。偏相关分析评估了PEF%与迈耶 - 科顿分级之间的关系，以及PEF%与呼吸暂停低通气指数（AHI）之间的关系。通过曼 - 惠特尼检验比较有和没有OSA的受试者的睡眠质量。
20名受试者参与；均为白人女性，平均年龄48.4（10.4）岁，体重指数（BMI）为24.1（3.8）。大多数（80%）患有特发性SGS，平均PEF为288（71）L/分钟。40%的受试者存在OSA，其中15%患有中度OSA。PEF%与AHI无相关性（>0.05）。70%的受试者睡眠质量差（PSQI≥5），20%有日间过度嗜睡（ESS>9）。有和没有OSA的受试者之间PSQI和ESS无差异（>0.05）。
SGS受试者队列中OSA患病率升高。有必要进一步研究气道扩张对OSA的影响。基于本研究结果，可能需要考虑对声门下狭窄患者进行OSA的筛查和监测。证据水平：3级。
