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晚期非小细胞肺癌患者的生活质量及与营养相关的方面

Quality of life and aspects related nutrition in advance stages non-small cell lung cancer patients.

作者信息

Hue Bui Thi Kim, Quyen Tran Chau, Dung Nguyen Quang, Ha Le Thu, Quang Bui Vinh, Nam Tran Thi, Loan Nguyen Thi

机构信息

Hanoi Oncology Hospital, Hanoi, Vietnam.

Vietnam National Institute of Nutrition, Hanoi, Vietnam.

出版信息

Nutr Health. 2024 Dec 10:2601060241299148. doi: 10.1177/02601060241299148.

Abstract

The quality of life (QoL) associated nutritional symptoms among advanced non-small cell lung cancer (NSCLC) patients remains uncertain. This study aimed to assess the impact of nutrition-related symptoms (indicated by Patient Generated Subjective Global Assessment-PG-SGA) to QoL among individuals diagnosed with advanced NSCLC, utilizing the EORTC QLQ-LC13 tool. A cross-sectional study included 170 patients diagnosed with NSCLC (TxNxM1) with periodically chemotherapy treatment at Hanoi Oncology hospital were invited to the study. The PG-SGA and EORTC QLQ-LC13 were assessed by a dietitian. Poor nutritional status related with decrease in QoL ( < 0.05). Cough and short of breath moderate-positively correlated with PG-SGA score, while pain, take medicine for pain and trouble swallowing were fairly correlated. The symptoms of cough up blood, sore mouth or tongue, tingling and hair lost had poor correlation with PG-SGA score. Loss of appetite and anorexia had poor negative correlation with short of breath and pain in arm or shoulder. QoL declined in advance stage NSCLC malnutrition patients. Nutrition-related symptoms had poor to fair correlation with QoL categories, which suggests the insufficiency on solely addressing nutritional symptoms to enhance QoL in this group.

摘要

晚期非小细胞肺癌(NSCLC)患者中与生活质量(QoL)相关的营养症状仍不明确。本研究旨在利用欧洲癌症研究与治疗组织(EORTC)QLQ-LC13工具,评估营养相关症状(由患者主观整体评定法-PG-SGA表示)对诊断为晚期NSCLC患者生活质量的影响。一项横断面研究邀请了170例在河内肿瘤医院接受定期化疗治疗、诊断为NSCLC(TxNxM1)的患者参与。PG-SGA和EORTC QLQ-LC13由一名营养师进行评估。营养状况不佳与生活质量下降相关(P<0.05)。咳嗽和气短与PG-SGA评分呈中度正相关,而疼痛、服用止痛药物和吞咽困难呈中等程度相关。咯血、口腔或舌部疼痛、刺痛和脱发症状与PG-SGA评分相关性较差。食欲不振和厌食与气短以及手臂或肩部疼痛呈弱负相关。晚期NSCLC营养不良患者的生活质量下降。营养相关症状与生活质量类别呈弱至中等程度相关,这表明仅解决营养症状以提高该组患者的生活质量是不够的。

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