Alsaffaf Yousef, Aldolly Ahmed, Arab Hazem, Alsolaiman Nour, Jalil Asaad, Youssef Simon, Ahmad Fariz
Faculty of Medicine, Hama University, Hama, Syria.
Pulmonary Department, Hama National Hospital, Hama, Syria.
Respir Med Case Rep. 2024 Nov 19;52:102143. doi: 10.1016/j.rmcr.2024.102143. eCollection 2024.
Pulmonary blastoma (PB) is a rare and aggressive lung neoplasm, representing 0.25 %-0.50 % of lung cancers and characterized by biphasic histology with both epithelial and mesenchymal components. We report a case of a 16-year-old male non-smoker presenting with hemoptysis and a 2-month history of dry cough and exertional dyspnea. Imaging revealed an ill-defined density in the left lung, and bronchoscopy identified a budding mass in the left bronchus. Biopsy results showed malignant spindle cells, with immunohistochemical staining positive for cytokeratin, vimentin, and TTF1, confirming classic biphasic pulmonary blastoma (CBPB). Further CT scans indicated multiple metastases in the right lung and bones. The patient was referred for palliative chemotherapy due to the tumor's aggressive nature. This case highlights the clinical presentation and diagnostic challenges of PB with endobronchial invasion.
肺母细胞瘤（PB）是一种罕见且侵袭性强的肺部肿瘤，占肺癌的0.25%-0.50%，其组织学特征为双相性，包含上皮和间充质成分。我们报告一例16岁不吸烟男性患者，表现为咯血，并有2个月干咳和劳力性呼吸困难病史。影像学检查显示左肺有边界不清的密度影，支气管镜检查发现左支气管内有一个芽状肿物。活检结果显示为恶性梭形细胞，免疫组化染色细胞角蛋白、波形蛋白和甲状腺转录因子1呈阳性，确诊为经典双相性肺母细胞瘤（CBPB）。进一步的CT扫描显示右肺和骨骼有多处转移。由于肿瘤具有侵袭性，该患者接受了姑息性化疗。本病例突出了PB伴支气管内侵犯的临床表现和诊断挑战。
