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印度对儿童营养不良的看法:患病率、病理生理学、风险因素及预防

Indian perspective on childhood malnutrition: Prevalence, pathophysiology, risk factors, and prevention.

作者信息

Mishra Malvika, Rao Yashwant Kumar, Shrivastav Dharmsheel, Tripathi Prashant, Singh Desh Deepak

机构信息

Department of Pediatrics, Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur 208002, Uttar Pradesh, India.

Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, Rajasthan, India.

出版信息

World J Clin Pediatr. 2024 Dec 9;13(4):91971. doi: 10.5409/wjcp.v13.i4.91971.

Abstract

BACKGROUND

Childhood malnutrition contributes over half of the childhood mortality around the world, predominantly in South-Asian and sub-Saharan countries.

AIM

To summarize the childhood malnutrition epidemiology along with the comorbid factors associated with it and its management within the community.

METHODS

The data collection process involved conducting a comprehensive search using specific keywords such as child nutrition disorders and India with Boolean operators. The search was conducted in the Scopus and PubMed electronic databases.

RESULTS

Inadequate energy consumption initiates pathological alterations in the form of growth retardation, fat, visceral, and muscle loss, a reduction in basal metabolic rate, and a significant reduction in total energy expenditure. It has become evident that malnutrition shows an increased prevalence and incidence rate, despite available guidelines for the management of malnutrition.

CONCLUSION

Malnutrition can be a major player in the establishment of severe infections that result in significant post discharge mortalities in children. Future trials are required to fill the prime gaps in knowledge regarding the identification of other contributory factors in the pathogenesis of malnutrition and post-discharge infection. New biomarkers for early detection of malnutrition should be the priority of the scientific community for the early management of malnutrition.

摘要

背景

儿童营养不良导致全球超过一半的儿童死亡,主要集中在南亚和撒哈拉以南国家。

目的

总结儿童营养不良的流行病学情况,以及与之相关的合并因素及其在社区中的管理。

方法

数据收集过程包括使用儿童营养障碍和印度等特定关键词以及布尔运算符进行全面搜索。搜索在Scopus和PubMed电子数据库中进行。

结果

能量摄入不足会引发病理改变,表现为生长发育迟缓、脂肪、内脏和肌肉流失、基础代谢率降低以及总能量消耗显著减少。尽管有营养不良管理指南,但营养不良的患病率和发病率仍呈上升趋势,这一点已变得很明显。

结论

营养不良可能是导致严重感染的主要因素,而严重感染会导致儿童出院后出现显著死亡。未来需要进行试验,以填补关于营养不良发病机制和出院后感染中其他促成因素识别方面的主要知识空白。用于早期检测营养不良的新生物标志物应成为科学界早期管理营养不良的优先事项。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f114/11572616/1bd423947b88/91971-g001.jpg

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