Li Longzhao, Bian Lingjie, Kou Na, Yuan Yue, Zou Heng
Respiratory Disease Center, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Integrative Traditional Chinese and Western Medicine, Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Front Immunol. 2024 Nov 25;15:1497259. doi: 10.3389/fimmu.2024.1497259. eCollection 2024.
This case report highlights the immune-related adverse events (irAEs) that occurred during the treatment of esophageal cancer with Tislelizumab and discusses management strategies, indicating that photodynamic therapy (PDT) may be an optimal adjunctive treatment option. Following Tislelizumab therapy, the patient demonstrated significant tumor reduction; however, subsequent irAEs related to immunotherapy emerged, including eyelid muscle weakness and myocardial and skeletal muscle injury. Methylprednisolone successfully alleviated these symptoms, with early intervention being crucial for controlling irAEs. The patient then underwent PDT, which not only further helped manage irAEs but also inhibited tumor progression. This case underscores the specific adverse reactions, such as eyelid ptosis, skeletal muscle, and myocardial damage associated with Tislelizumab, and the importance of early corticosteroid intervention. It also emphasizes the significance of PDT as an adjunctive treatment for controlling tumors and alleviating immune-related adverse reactions.
本病例报告重点介绍了替雷利珠单抗治疗食管癌期间发生的免疫相关不良事件（irAEs），并讨论了管理策略，表明光动力疗法（PDT）可能是一种最佳的辅助治疗选择。接受替雷利珠单抗治疗后，患者肿瘤显著缩小；然而，随后出现了与免疫治疗相关的irAEs，包括眼睑肌无力以及心肌和骨骼肌损伤。甲泼尼龙成功缓解了这些症状，早期干预对于控制irAEs至关重要。患者随后接受了PDT，这不仅进一步有助于管理irAEs，还抑制了肿瘤进展。该病例强调了与替雷利珠单抗相关的特定不良反应，如眼睑下垂、骨骼肌和心肌损伤，以及早期皮质类固醇干预的重要性。它还强调了PDT作为控制肿瘤和减轻免疫相关不良反应的辅助治疗的重要性。
