Nizamani Misbah
Dow Medical College, DUHS.
Sarcoidosis Vasc Diffuse Lung Dis. 2024 Dec 10;41(4):e2024036. doi: 10.36141/svdld.v41i4.15873.
Sarcoidosis is a multi-system disorder characterized by the formation of non-caseating granulomas. It is a disorder of unknown etiology. Interferon-induced sarcoidosis is a well-known phenomenon. However, in the past few years, few cases have come forward in which after treatment with a monoclonal antibody, Alemtuzumab, patients developed sarcoidosis. This antibody targets the pan-lymphocyte CD52 antigen found on both human lymphoid and myeloid cells and is used in the treatment of Relapsing Remitting Multiple Sclerosis, leukemia, etc. Patients, in these cases, after a few years of treatment developed sarcoidosis but fortunately responded well to the treatment, if needed.
结节病是一种以非干酪样肉芽肿形成为特征的多系统疾病。它是一种病因不明的疾病。干扰素诱导的结节病是一种众所周知的现象。然而，在过去几年中，很少有病例出现，即使用单克隆抗体阿仑单抗治疗后，患者发生了结节病。这种抗体靶向人类淋巴细胞和髓细胞上发现的全淋巴细胞CD52抗原，用于治疗复发缓解型多发性硬化症、白血病等。在这些病例中，患者在接受数年治疗后发生了结节病，但幸运的是，如果需要，对治疗反应良好。
