Warren L R, Butler R W, Katholi C R, Halsey J H
J Gerontol. 1985 Jan;40(1):53-9. doi: 10.1093/geronj/40.1.53.
This experiment compared the diffuse and regional cerebral blood flow (CBF) during rest and during cognitive activation with and without incentive-induced arousal in young, middle-aged, and older adults. Two normal rest CBF measurements were followed by two mental mathematics activation CBF measurements. For the first activation measurement, half the participants in each age group were offered monetary incentive for correct performance and half the participants received no monetary incentive. All participants were offered monetary incentive on the final activation measurement. Older participants had lower resting blood flow at all detectors, but age-related reductions in blood flow were statistically significant only in anterior and inferior rolandic regions. The effect of monetary incentive was to increase blood flow at the inferior rolandic detector in both hemispheres. The CBF response to cognitive activation and monetary incentive did not differ in the three age groups.
本实验比较了年轻人、中年人和老年人在静息状态以及在有或无激励引起的觉醒情况下认知激活期间的全脑和局部脑血流量（CBF）。在进行两次正常静息CBF测量之后，接着进行两次心算激活CBF测量。对于第一次激活测量，每个年龄组中有一半参与者因表现正确而获得金钱奖励，另一半参与者没有获得金钱奖励。在最后一次激活测量时，所有参与者都获得了金钱奖励。老年参与者在所有检测部位的静息血流量较低，但与年龄相关的血流量减少仅在罗兰区前部和下部具有统计学意义。金钱奖励的作用是增加两个半球罗兰区下部检测部位的血流量。三个年龄组对认知激活和金钱奖励的CBF反应没有差异。
