Gulle Bugra Taygun, Kiran Pinar, Celik Saadet Goksu, Varol Zeynep Sedef, Siyve Neslisah, Emecen Ahmet Naci, Duzel Hilal
Faculty of Medicine, Department of Public Health, Division of Epidemiology, Dokuz Eylül University, Izmir, Turkey.
Faculty of Medicine, Department of Public Health, Dokuz Eylül University, Izmir, Turkey.
Epidemiol Infect. 2024 Dec 10;152:e165. doi: 10.1017/S0950268824001596.
Cervical cancer, closely linked to human papillomavirus (HPV) infection, is a major global health concern. Our study aims to fill the gap in understanding HPV vaccine awareness and acceptance in the Middle East, where national immunization programs are often lacking and cultural perceptions hinder acceptance. This systematic review and meta-analysis adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive literature search across several databases was conducted on 5 September 2023. We included quantitative studies on HPV vaccine awareness and acceptance in Middle Eastern countries. Data extraction and quality assessment were conducted independently by multiple reviewers to ensure accuracy. Statistical analyses, including subgroup analyses, were performed using R to calculate pooled estimates, assess heterogeneity, and publication bias. We reviewed 159 articles from 15 Middle Eastern countries, focusing on 93,730 participants, predominantly female and healthcare workers. HPV vaccine awareness was found to be 41.7% (95% CI 37.4%-46.1%), with higher awareness among healthcare workers. The pooled acceptance rate was 45.6% (95% CI 41.3%-50.1%), with similar rates between healthcare and non-healthcare workers. Our study highlights the critical need for increased HPV vaccine awareness and acceptance in the Middle East, emphasizing the importance of integrating the vaccine into national immunization programs and addressing cultural and religious factors to improve public health outcomes.
宫颈癌与人类乳头瘤病毒（HPV）感染密切相关，是全球主要的健康问题。我们的研究旨在填补中东地区在HPV疫苗认知和接受度方面的认知空白，该地区往往缺乏国家免疫规划，且文化观念阻碍了疫苗的接受。本系统评价和荟萃分析遵循系统评价和荟萃分析的首选报告项目指南。2023年9月5日，我们在多个数据库中进行了全面的文献检索。我们纳入了关于中东国家HPV疫苗认知和接受度的定量研究。由多名评审员独立进行数据提取和质量评估，以确保准确性。使用R软件进行统计分析，包括亚组分析，以计算合并估计值、评估异质性和发表偏倚。我们回顾了来自15个中东国家的159篇文章，重点关注93730名参与者，其中主要是女性和医护人员。发现HPV疫苗认知率为41.7%（95%CI 37.4%-46.1%），医护人员的认知率更高。合并接受率为45.6%（95%CI 41.3%-50.1%），医护人员和非医护人员的接受率相似。我们的研究强调了在中东地区提高HPV疫苗认知和接受度的迫切需求，强调了将疫苗纳入国家免疫规划以及解决文化和宗教因素以改善公共卫生结果的重要性。
