结直肠癌研究中的创新：以SPACA6P-AS为进展靶点

Ma Tianyi, Jin Yinghu, Wang Song, Hu Hanqing, Wang Meng, Yan Guoqing, Tang Qingchao, Huang Rui, Wang Guiyu

Department of Colorectal Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Department of Colorectal Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

J Biochem Mol Toxicol. 2024 Dec;38(12):e70039. doi: 10.1002/jbt.70039.

The purpose of this research was to provide light on the functional role that the long noncoding RNA SPACA6P-AS plays in the biology of colorectal cancer (CRC). The presence of elevated SPACA6P-AS expression in colorectal cancer tissues is linked to advanced stages of the disease as well as a decreased overall survival rate. It has been demonstrated through knockdown tests conducted on CRC cell lines that SPACA6P-AS stimulates cell growth in both in vitro and in vivo settings. By acting as a competing endogenous RNA, SPACA6P-AS is able to modulate the levels of miR-339-5p and promote the proliferation of colorectal cancer cells by way of the miR-339-5p/FAM167AFAM167A signaling axis. Based on these findings, SPACA6P-AS is a promising candidate for both a prognostic marker and a therapeutic target in colorectal cancer.

本研究的目的是阐明长链非编码RNA SPACA6P-AS在结直肠癌（CRC）生物学中的功能作用。结直肠癌组织中SPACA6P-AS表达升高与疾病的晚期阶段以及总体生存率降低有关。通过对CRC细胞系进行的敲低试验表明，SPACA6P-AS在体外和体内环境中均能刺激细胞生长。作为一种竞争性内源性RNA，SPACA6P-AS能够调节miR-339-5p的水平，并通过miR-339-5p/FAM167AFAM167A信号轴促进结直肠癌细胞的增殖。基于这些发现，SPACA6P-AS有望成为结直肠癌的预后标志物和治疗靶点。