一种用于定量缺氧神经元中硝基还原酶的比率型双光子荧光探针。
A ratiometric two-photon fluorescent probe for the quantification of nitroreductase in hypoxic neurons.
作者信息
Tang Zhiquan, Huang Hong, Yao Yuanyuan, Gao Shumei, Lin Bingyong, Zong Qianshou, Hu Wanpeng, Xu Jianguo, Wang Yangang, Guo Longhua
机构信息
College of Biological, Chemical Science and Engineering, Jiaxing University, Jiaxing 314001, China.
出版信息
Chem Commun (Camb). 2025 Jan 2;61(3):560-563. doi: 10.1039/d4cc06218c.
PMID:39655867
Abstract
We developed a novel ratiometric two-photon fluorescent probe for the selective and precise detection of nitroreductase (NTR) in neurons. Using this probe, we found that hypoxic stimulation could up-regulate endogenous NTR levels.
摘要
我们开发了一种新型的比率型双光子荧光探针，用于选择性和精确地检测神经元中的硝基还原酶（NTR）。使用该探针，我们发现缺氧刺激可上调内源性NTR水平。
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