Mousavi Shahrzad, Khazaee-Nasirabadi Mohammad Hossein, Seyedmehdi Maryam Sadat, Bazi Ali, Mirzaee Khalilabadi Roohollah
Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Hematology and Medical Laboratory Sciences, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Leuk Lymphoma. 2025 Apr;66(4):594-616. doi: 10.1080/10428194.2024.2438802. Epub 2024 Dec 10.
In recent times, the application of CAR-T cell treatment has significantly progressed, showing auspicious treatment outcomes in hematologic malignancies. However, along with these advances, certain limitations and challenges hurdle the widespread utilization of this technology. Recently, CAR-NK cells have gained attention in cancer treatment, as this approach has an important advantage over CART therapy (i.e. no need for HLA matching) for targeting foreign cells. This review aims to explore the benefits of CAR NK cell therapy, and generation strategies, as well as the challenges and limitations hindering the application of CAR NK cells in experimental studies and trials on hematologic malignancies.
