Raines A, Mahany T M, Baizer L, Swope S, Hershkowitz N
J Pharmacol Exp Ther. 1985 Jan;232(1):283-94.
Phenytoin (DPH) was evaluated for its capacity to reduce several motor manifestations of decerebrate rigidity in the cat. In doses of the order of 40 to 50 mg/kg i.v., DPH diminished the force necessary to collapse the hyperextended limbs; at about half this dose range, the drug reduced gamma-motoneuron discharges; at still lower doses the drug profoundly depressed mechanical and electromyographic responses evoked by stretch from both forelimb and hindlimb extensor muscles. Serum levels of DPH associated with substantial reduction in electrical and mechanical manifestations of the extensor hypertonus were of the same order conventionally encountered when the drug is administered to humans for acute seizure management. The data are supportive of a centrally and peripherally mediated muscle relaxing effect of the drug in states where muscle spindle involvement is a contributing factor, and may help to explain further the utility of DPH in the treatment of spasticity.
对苯妥英（DPH）降低猫去大脑强直的几种运动表现的能力进行了评估。静脉注射剂量为40至50mg/kg左右时，DPH可减少使过度伸展的肢体塌陷所需的力量；在该剂量范围的大约一半时，该药可减少γ运动神经元放电；在更低剂量时，该药可显著抑制前肢和后肢伸肌肌肉伸展所诱发的机械和肌电图反应。与伸肌张力过高的电和机械表现大幅降低相关的DPH血清水平，与该药用于人类急性癫痫治疗时通常遇到的水平相当。这些数据支持该药在肌肉纺锤体参与起作用的状态下具有中枢和外周介导的肌肉松弛作用，并可能有助于进一步解释DPH在治疗痉挛方面的效用。
