一些季铵烷基化剂的合成及其对梭曼抑制的乙酰胆碱酯酶的影响。
Synthesis of some quaternary ammonium alkylating agents and their effects on soman-inhibited acetylcholinesterase.
作者信息
Gray A P, Platz R D, Chang T C, Leverone T R, Ferrick D A, Kramer D N
出版信息
J Med Chem. 1985 Jan;28(1):111-6. doi: 10.1021/jm00379a020.
PMID:3965704
Abstract
A number of compounds were synthesized and tested for their ability to realkylate the phosphonate anion of "aged", soman-inhibited acetylcholinesterase. None were found able to do so, but two of the compounds in particular, [2-(4-pyridyl)ethyl]diethylmethylammonium iodide (6) and its 2-isomer 7, proved able to slow the rate of aging significantly.
摘要
合成了许多化合物，并测试了它们使“老化的”梭曼抑制的乙酰胆碱酯酶的膦酸酯阴离子再烷基化的能力。未发现有化合物能够做到这一点，但其中两种化合物，特别是[2-(4-吡啶基)乙基]二乙甲基碘化铵(6)及其2-异构体7，被证明能够显著减缓老化速率。
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