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有机磷抑制的乙酰胆碱酯酶的重活化剂。1. 咪唑肟衍生物。

Reactivators of organophosphorus-inhibited acetylcholinesterase. 1. Imidazole oxime derivatives.

作者信息

Herrador M M, Saénz de Buruaga J, Suarez M D

出版信息

J Med Chem. 1985 Jan;28(1):146-9. doi: 10.1021/jm00379a026.

DOI:10.1021/jm00379a026
PMID:3965707
Abstract

4-[(Hydroxyimino)methyl]-3-methylimidazolium iodides were prepared and tested for their reactivating potency on acetylcholinesterase inhibited by tetraethyl pyrophosphate (TEPP). The in vitro testing revealed that the new compounds are weak reactivators of the phosphorylated electrophorus acetylcholinesterase.

摘要

制备了4-[(羟基亚氨基)甲基]-3-甲基咪唑碘化物，并测试了它们对由焦磷酸四乙酯（TEPP）抑制的乙酰胆碱酯酶的复活效力。体外测试表明，这些新化合物是磷酸化电鳗乙酰胆碱酯酶的弱复活剂。

相似文献

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Reactivators of organophosphorus-inhibited acetylcholinesterase. 1. Imidazole oxime derivatives.有机磷抑制的乙酰胆碱酯酶的重活化剂。1. 咪唑肟衍生物。
J Med Chem. 1985 Jan;28(1):146-9. doi: 10.1021/jm00379a026.
2
Structure-activity relationships for reactivators of organophosphorus-inhibited acetylcholinesterase: quaternary salts of 2-[(hydroxyimino)methyl]imidazole.有机磷抑制的乙酰胆碱酯酶重活化剂的构效关系：2-[(羟基亚氨基)甲基]咪唑的季铵盐
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Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase.乌吉多组分反应在神经毒剂抑制的乙酰胆碱酯酶再活化剂合成中的应用。
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Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro.乙酰胆碱酯酶、有毒有机磷化合物与一系列结构相关的非肟类重活化剂之间的相互作用：体外重活化和抑制动力学分析。
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[Structure-activity relationships in reactivators of acetylcholinesterase inhibited by organophosphoric compounds. 8. Halides of 2- and 4-hydroxy-iminomethyl-1-(omega-(4-imidazolyl)-n-alkyl)pyridinium].[有机磷化合物抑制的乙酰胆碱酯酶复活剂的构效关系。8. 2-和4-羟基-亚氨基甲基-1-(ω-(4-咪唑基)-正烷基)吡啶鎓的卤化物]
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Structure-activity relationships in reactivators of organophosphorus-inhibited acetylcholinesterase. 7. 1-Aryl-2-hydroxyiminomethyl-3-methylimidazolium iodides.有机磷抑制的乙酰胆碱酯酶复活剂的构效关系。7. 1-芳基-2-羟基亚氨基甲基-3-甲基咪唑碘化物。
J Med Chem. 1974 Jan;17(1):18-22. doi: 10.1021/jm00247a005.
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Structure-activity relationships in reactivators of organophosphorus-inhibited acetylcholinesterase. 9. N-Heterocyclic acraldoximes methiodides.有机磷抑制的乙酰胆碱酯酶重活化剂的构效关系。9. N-杂环丙烯醛肟甲基碘化物。
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Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE).双季铵盐 2-(羟基亚氨基)-N-(吡啶-3-基)乙酰胺衍生物作为沙林和 VX 抑制人乙酰胆碱酯酶 (hAChE) 的重活化剂的合成及体外评价
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Structure-activity relationships in reactivators of organophosphorus-inhibited acetylcholinesterase. 6. 2-Hydroxyiminomethylimidazolium iodides.
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Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.2-[(羟基亚氨基)甲基]咪唑的季铵盐。2. 1-(烷氧基甲基)-2-[(羟基亚氨基)甲基]-3-甲基咪唑鎓卤化物用于复活有机磷抑制的乙酰胆碱酯酶的制备及体外和体内评价
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引用本文的文献

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Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification.咪唑醛肟有效辅助丁酰胆碱酯酶对有机磷解毒。
J Med Chem. 2014 Feb 27;57(4):1378-89. doi: 10.1021/jm401650z. Epub 2014 Feb 7.