有机磷抑制的乙酰胆碱酯酶的重活化剂。1. 咪唑肟衍生物。
Reactivators of organophosphorus-inhibited acetylcholinesterase. 1. Imidazole oxime derivatives.
作者信息
Herrador M M, Saénz de Buruaga J, Suarez M D
出版信息
J Med Chem. 1985 Jan;28(1):146-9. doi: 10.1021/jm00379a026.
PMID:3965707
Abstract
4-[(Hydroxyimino)methyl]-3-methylimidazolium iodides were prepared and tested for their reactivating potency on acetylcholinesterase inhibited by tetraethyl pyrophosphate (TEPP). The in vitro testing revealed that the new compounds are weak reactivators of the phosphorylated electrophorus acetylcholinesterase.
摘要
制备了4-[(羟基亚氨基)甲基]-3-甲基咪唑碘化物，并测试了它们对由焦磷酸四乙酯（TEPP）抑制的乙酰胆碱酯酶的复活效力。体外测试表明，这些新化合物是磷酸化电鳗乙酰胆碱酯酶的弱复活剂。
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