线粒体功能障碍中的α-突触核蛋白：机遇还是障碍。 - Suppr

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超能文献

Alpha-synuclein in mitochondrial dysfunction: opportunities or obstacles.

作者信息

Gunawardena Shermali

机构信息

Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, NY, USA.

出版信息

Neural Regen Res. 2025 Jan 1;20(1):197-198. doi: 10.4103/NRR.NRR-D-23-01966. Epub 2024 Apr 3.

DOI:10.4103/NRR.NRR-D-23-01966

PMID:39657088

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11246122/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af18/11246122/a6f7584671cb/NRR-20-197-g001.jpg

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Cells. 2023 Oct 5;12(19):2406. doi: 10.3390/cells12192406.

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.α-突触核蛋白在丝氨酸 129 的磷酸化发生在初始蛋白沉积之后，并抑制种子纤维形成和毒性。

Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2109617119. doi: 10.1073/pnas.2109617119. Epub 2022 Mar 30.

Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Familial Parkinson's Disease Patients Display α-Synuclein Pathology and Abnormal Mitochondrial Morphology.家族性帕金森病患者诱导多能干细胞衍生的多巴胺能神经元显示α-突触核蛋白病理学和异常的线粒体形态。

Cells. 2021 Sep 13;10(9):2402. doi: 10.3390/cells10092402.

Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation.α-突触核蛋白在 DRP1 依赖性分裂和 PINK1/Parkin 介导的氧化中的差异线粒体作用。

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