Li Bowen, Xu Jianguo, Zheng Qingyong, Gao Jie, Ren Qian, Zhou Yongning
Department of Pediatrics, the First Hospital of Lanzhou University, Lanzhou 730000, China.
The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China.
J Clin Endocrinol Metab. 2024 Dec 6. doi: 10.1210/clinem/dgae843.
This study aimed to investigate the causal effects of metabolic syndrome (MetS) components, including fasting blood glucose (FBG), HDL cholesterol (HDL-C), triglycerides (TG), waist circumference (WC), and hypertension, on the risks of chronic gastritis, benign gastric tumors, and gastric cancer using Mendelian randomization (MR) analyses.
Univariable two-sample Mendelian randomization (TSMR) and multivariable Mendelian randomization (MVMR) analyses were employed to evaluate the independent and combined effects of MetS components on gastric disorders. The primary MR method used was the random effects inverse variance weighted (IVW) approach.
Univariable TSMR analysis identified significant associations between elevated TG (OR = 1.223, 95% CI: 1.011-1.480, p = 0.0386) and reduced HDL-C (OR = 0.833, 95% CI: 0.701-0.989, p = 0.037) with an increased risk of benign gastric tumors. However, these associations were not confirmed by MVMR for TG (OR = 1.187, 95% CI: 0.891-1.581, p = 0.2408) or HDL-C (OR = 0.989, 95% CI: 0.758-1.289, p = 0.932). Both TSMR (OR = 0.585, 95% CI: 0.411-0.831, p = 0.003) and MVMR (OR = 0.558, 95% CI: 0.334-0.930, p = 0.025) indicated that hypertension is associated with a reduced risk of gastric cancer. No significant associations were found for other MetS components and gastric disorders.
The findings suggest that specific MetS components, such as TG and HDL-C, may affect the risk of benign gastric tumors, while hypertension might reduce the risk of gastric cancer. This study highlights the need for further research to understand the underlying mechanisms and potential indirect effects between MetS components and gastric disorders.
本研究旨在利用孟德尔随机化（MR）分析，探讨代谢综合征（MetS）各组分，包括空腹血糖（FBG）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、腰围（WC）和高血压，对慢性胃炎、胃良性肿瘤和胃癌风险的因果效应。
采用单变量双样本孟德尔随机化（TSMR）和多变量孟德尔随机化（MVMR）分析，评估MetS各组分对胃部疾病的独立和联合效应。使用的主要MR方法是随机效应逆方差加权（IVW）法。
单变量TSMR分析发现，TG升高（OR = 1.223，95%CI：1.011 - 1.480，p = 0.0386）和HDL-C降低（OR = 0.833，95%CI：0.701 - 0.989，p = 0.037）与胃良性肿瘤风险增加显著相关。然而，MVMR分析未证实TG（OR = 1.187，95%CI：0.891 - 1.581，p = 0.2408）或HDL-C（OR = 0.989，95%CI：0.758 - 1.289，p = 0.932）存在这种关联。TSMR（OR = 0.585，95%CI：0.411 - 0.831，p = 0.003）和MVMR（OR = 0.558，95%CI：0.334 - 0.930，p = 0.025）均表明高血压与胃癌风险降低有关。未发现其他MetS组分与胃部疾病之间存在显著关联。
研究结果表明，特定的MetS组分，如TG和HDL-C，可能影响胃良性肿瘤的风险，但高血压可能降低胃癌风险。本研究强调需要进一步研究，以了解MetS组分与胃部疾病之间的潜在机制和间接效应。
