Lemmens Cynthia M C, Vanhommerig Joost W, Knottnerus Bart J, Uitdehaag Bernard M J, Mostert Jop P, de Jong Brigit A
Department of Neurology, Haaglanden Medical Center, Lijnbaan 32, The Hague 2512 VA, The Netherlands; Department of Neurology, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam Neuroscience, MS Center Amsterdam, Amsterdam, The Netherlands.
Department of General Practice Care, Netherlands Institute for Health Services Research (Nivel), Utrecht, The Netherlands.
Mult Scler Relat Disord. 2025 Jan;93:106207. doi: 10.1016/j.msard.2024.106207. Epub 2024 Dec 1.
The rising prevalence estimates of multiple sclerosis (MS) globally underscore the imperative for up-to-date epidemiological data specific to the Netherlands.
Data from two Dutch healthcare databases (Nivel Primary Care Database and Vektis Database) comprising both general practices and hospital electronic health records in 2019 were combined to assess age- and sex-standardized MS prevalence and incidence estimates. Differences in prevalence estimates based on latitude and between primary versus secondary care records were examined.
The age and sex-standardized prevalence estimate was 210.4 per 100,000 inhabitants. Incidence estimate of MS was 7.1 per 100,000 person-years within the year 2019. One-third of the MS cohort from primary care records was not documented in the hospital database over two consecutive years. Prevalence estimates were higher in northern areas versus southern areas (respectively 240.6 versus 208.3 per 100,000 inhabitants).
Aligning results from different global regions, prevalence estimates of MS in the Netherlands have increased significantly over the last decennia, while incidence estimates are stable. The discrepancy between MS records within the primary and secondary care setting could indicate that a substantial proportion of Dutch patients with MS are not under specialized neurological care.
全球多发性硬化症（MS）患病率估计值不断上升，凸显了获取荷兰最新特定流行病学数据的必要性。
合并来自两个荷兰医疗保健数据库（Nivel初级保健数据库和Vektis数据库）的数据，这些数据包含2019年的全科医疗和医院电子健康记录，以评估年龄和性别标准化的MS患病率和发病率估计值。研究了基于纬度以及初级保健与二级保健记录之间患病率估计值的差异。
年龄和性别标准化患病率估计为每10万居民210.4例。2019年MS的发病率估计为每10万人年7.1例。连续两年，初级保健记录中的MS队列中有三分之一未在医院数据库中记录。北部地区的患病率估计高于南部地区（分别为每10万居民240.6例和208.3例）。
与全球不同地区的结果一致，荷兰MS的患病率估计在过去十年中显著增加，而发病率估计保持稳定。初级保健和二级保健环境中MS记录之间的差异可能表明，相当一部分荷兰MS患者未接受专科神经护理。
