卵圆孔未闭患者甘油三酯-葡萄糖指数与隐源性卒中的关系

The Relationship Between the Triglyceride-Glucose Index and Cryptogenic Stroke in Patients with Patent Foramen Ovale.

作者信息

Esin Fatma, Ince Hüseyin Sefa, Aktürk Semih, Citekci Fahrettin Tugrul, Celik Aykan, Kocabas Ugur, Kiris Tuncay, Karaca Mustafa

机构信息

Department of Cardiology, Izmir Katip Çelebi University, Atatürk Training and Research Hospital, Izmir, Turkey.

出版信息

Clin Appl Thromb Hemost. 2024 Jan-Dec;30:10760296241301411. doi: 10.1177/10760296241301411.

DOI:10.1177/10760296241301411

PMID:39658016

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11632868/

Abstract

OBJECTIVE

This study aimed to investigate the association between the triglyceride-glucose (TyG) index and cryptogenic stroke (CS) in patients diagnosed with patent foramen ovale (PFO) using transesophageal echocardiography (TEE).

METHODS

A retrospective, single-center study was conducted at a tertiary education and research hospital from January 2015 to December 2023. The study population included 1017 consecutive patients with sinus rhythm diagnosed with PFO, of whom 210 had CS. The TyG Index was calculated using triglyceride and fasting glucose levels.

RESULTS

Patients with CS were older (47.53 ± 12.34 years) compared to control group (44.40 ± 17.82 years, p = .005). The proportion of males was higher in the CS group (56.2%) compared to the control group (48.3%, p = .042). Laboratory findings revealed higher TyG Index (8.87 ± 0.51 vs 8.63 ± 0.55, p < .001) in patients with CS. TyG Index was an independent predictor of CS in patients with PFO (OR: 2.832, 95%CI: 1.979-4.053 p < .001).

CONCLUSION

Elevated TyG Index levels was associated with CS in patients with PFO. The TyG index may serve as a useful biomarker for assessing CS risk in this population.

摘要

目的

本研究旨在探讨经食管超声心动图（TEE）诊断为卵圆孔未闭（PFO）的患者中，甘油三酯-葡萄糖（TyG）指数与隐源性卒中（CS）之间的关联。

方法

2015年1月至2023年12月在一家三级教育和研究医院进行了一项回顾性单中心研究。研究人群包括1017例连续诊断为PFO且窦性心律的患者，其中210例患有CS。使用甘油三酯和空腹血糖水平计算TyG指数。

结果

与对照组（44.40±17.82岁，p = 0.005）相比，CS患者年龄更大（47.53±12.34岁）。CS组男性比例（56.2%）高于对照组（48.3%，p = 0.042）。实验室检查结果显示，CS患者的TyG指数更高（8.87±0.51 vs 8.63±0.55，p < 0.001）。TyG指数是PFO患者发生CS的独立预测因素（OR：2.832，95%CI：1.979 - 4.053，p < 0.001）。