Huang Jie, van der Hoorn Renier A L
The Plant Chemetics Laboratory, Department of Biology, University of Oxford, OX1 3RB Oxford, UK.
J Exp Bot. 2024 Dec 10. doi: 10.1093/jxb/erae496.
Over the past decades, numerous studies have demonstrated that proteases serve as a crucial regulatory mechanism in controlling plant immunity. In this review, we specifically focus on the role of one subfamily of RD21-like papain-like cysteine proteases that carry a C-terminal granulin domain. These proteases share high homology but have been described under very different names in different plant species. We provide a comprehensive overview of the background, endogenous regulation, and subcellular localization of RD21-like proteases in plants. Notably, RD21-like proteases act in immunity against various pathogens and they are targeted by many unrelated pathogen-secreted effectors that inactivate, mislocalise or degrade RD21-like proteases. We highlight open questions and strategies to use this knowledge to develop innovative strategies for crop protection.
在过去几十年中，大量研究表明蛋白酶在控制植物免疫方面起着关键的调节作用。在本综述中，我们特别关注携带C端颗粒蛋白结构域的RD21样木瓜蛋白酶样半胱氨酸蛋白酶亚家族的作用。这些蛋白酶具有高度同源性，但在不同植物物种中却以非常不同的名称被描述。我们全面概述了植物中RD21样蛋白酶的背景、内源性调节和亚细胞定位。值得注意的是，RD21样蛋白酶在抵御各种病原体的免疫中发挥作用，并且它们被许多不相关的病原体分泌效应子靶向，这些效应子会使RD21样蛋白酶失活、错误定位或降解。我们强调了悬而未决的问题以及利用这些知识开发作物保护创新策略的方法。
