单不饱和脂肪酸与肺癌之间的因果关联：一项两样本孟德尔随机化研究。
Causal Association Between Monounsaturated Fatty Acids and Lung Cancer: A Two-Sample Mendelian Randomization Study.
作者信息
Zhang Shaofeng, Jiang Jia, Wu Xiping, Liu Jiayi, Lei Wei, Chen Siqin, Zeng Yaling, Liu Xiang, Xiao Qiang
机构信息
Pulmonary and Critical Care Medicine, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, Guangdong, China.
Pulmonary and Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
出版信息
Clin Respir J. 2024 Dec;18(12):e70038. doi: 10.1111/crj.70038.
OBJECTIVE
This study aims to investigate the potential causal relationship between monounsaturated fatty acids (MUFAs) and lung cancer.
METHODS
Genetic data on MUFAs and pathological subtypes of lung cancer were extracted from genome-wide association studies (GWAS). The primary analysis utilized inverse-variance weighted analysis (IVW), with additional methods including the weighted median method, MR-Egger regression method, and weighted model method. Sensitivity analysis was conducted to assess the robustness of the findings.
RESULTS
The inverse variance-weighted (IVW) analysis of monounsaturated fatty acids in relation to lung adenocarcinoma yielded an odds ratio (OR) of 1.059 with a 95% confidence interval of 0.960 to 1.168 and a p value of 0.252. Similarly, for lung squamous cell carcinoma, the IVW analysis produced odd ratios of 0.884, 95% confidence intervals of 0.747 to 1.045, and a p value of 0.148. In the case of small cell lung cancer, the odds ratio was 0.936, the 95% confidence interval was 0.751 to 1.166, and the p value was 0.554.
CONCLUSION
It can be concluded that there is no direct causal relationship between monounsaturated fatty acids and the development of lung cancer.
目的
本研究旨在探讨单不饱和脂肪酸（MUFAs）与肺癌之间潜在的因果关系。
方法
从全基因组关联研究（GWAS）中提取关于MUFAs和肺癌病理亚型的遗传数据。主要分析采用逆方差加权分析（IVW），其他方法包括加权中位数法、MR-Egger回归法和加权模型法。进行敏感性分析以评估研究结果的稳健性。
结果
单不饱和脂肪酸与肺腺癌的逆方差加权（IVW）分析得出优势比（OR）为1.059，95%置信区间为0.960至1.168，p值为0.252。同样，对于肺鳞状细胞癌，IVW分析得出优势比为0.884，95%置信区间为0.747至1.045，p值为0.148。对于小细胞肺癌，优势比为0.936，95%置信区间为0.751至1.166，p值为0.554。
结论
可以得出结论，单不饱和脂肪酸与肺癌的发生之间不存在直接因果关系。
Zotero 插件