Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, VIC, Australia.
Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Lancet. 2021 Aug 7;398(10299):535-554. doi: 10.1016/S0140-6736(21)00312-3. Epub 2021 Jul 21.
Lung cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths worldwide with an estimated 2 million new cases and 1·76 million deaths per year. Substantial improvements in our understanding of disease biology, application of predictive biomarkers, and refinements in treatment have led to remarkable progress in the past two decades and transformed outcomes for many patients. This seminar provides an overview of advances in the screening, diagnosis, and treatment of non-small-cell lung cancer and small-cell lung cancer, with a particular focus on targeted therapies and immune checkpoint inhibitors.
肺癌是最常见的癌症之一，也是全球癌症相关死亡的主要原因，每年估计有 200 万新发病例和 176 万人死亡。对疾病生物学的理解、预测生物标志物的应用以及治疗方法的改进，在过去二十年取得了显著进展，改变了许多患者的预后。本研讨会概述了非小细胞肺癌和小细胞肺癌的筛查、诊断和治疗方面的进展，特别关注了靶向治疗和免疫检查点抑制剂。
