Barbieri Emiliano, Bonet Jacopo, Fox Delaney, Nelson Rafaela, Nelson Michael B, Nelson Loretta, Fernandez Cristina, Van Name Michelle, Samuels Stephanie, Caprio Sonia, Sabati Mohammad, Galderisi Alfonso, Sherr Jennifer, Dalla Man Chiara, Santoro Nicola
Scuola di Specializzazione in Pediatria, Universita' Federico II, Naples, Italy.
Department of Information Engineering, University of Padova, Padua, Italy.
Obesity (Silver Spring). 2025 Jan;33(1):116-124. doi: 10.1002/oby.24175. Epub 2024 Dec 10.
Pediatric obesity is associated with insulin resistance, which, in turn, impacts glucose and lipid metabolism. This study sought to assess how glucose variability relates to intrahepatic fat content, β cell insulin sensitivity, and glycolysis in youth with obesity.
A total of 27 youth with obesity (11 girls, BMI percentile, median [25th-75th percentiles]: 99.0 [97.9-99.0]) wore a continuous glucose monitoring device for 10 days and underwent a 3-h oral glucose tolerance test. β cell function was assessed using the oral minimal model, and liver proton density fat fraction was measured by magnetic resonance imaging.
Average sensor-derived glucose and glucose standard deviation (STDEV) and coefficient of variation (CV) were associated with liver proton density fat fraction (p = 0.0130, p = 0.0005, and p = 0.0028, respectively). First-phase insulin secretion, basal insulin secretion, and insulin sensitivity were associated with STDEV (p = 0.0344, p = 0.0091, and p = 0.0031, respectively) and CV (p = 0.0128, p = 0.0012, and p = 0.0022, respectively). STDEV and CV were also associated with 2-h glucose (p = 0.0067 and p = 0.0324, respectively) and plasma lactate (p = 0.0030 and p = 0.0123, respectively).
Daily glucose variability is associated with the degree of intrahepatic fat content, postprandial glucose, and plasma lactate concentrations.
儿童肥胖与胰岛素抵抗相关，而胰岛素抵抗又会影响葡萄糖和脂质代谢。本研究旨在评估肥胖青少年的血糖变异性与肝内脂肪含量、β细胞胰岛素敏感性和糖酵解之间的关系。
共有27名肥胖青少年（11名女孩，BMI百分位数，中位数[第25 - 75百分位数]：99.0[97.9 - 99.0]）佩戴连续血糖监测设备10天，并接受3小时口服葡萄糖耐量试验。使用口服最小模型评估β细胞功能，通过磁共振成像测量肝脏质子密度脂肪分数。
传感器得出的平均血糖、血糖标准差（STDEV）和变异系数（CV）与肝脏质子密度脂肪分数相关（分别为p = 0.0130、p = 0.0005和p = 0.0028）。第一相胰岛素分泌、基础胰岛素分泌和胰岛素敏感性与STDEV（分别为p = 0.0344、p = 0.0091和p = 0.0031）和CV（分别为p = 0.0128、p = 0.0012和p = 0.0022）相关。STDEV和CV还与2小时血糖（分别为p = 0.0067和p = 0.0324）以及血浆乳酸（分别为p = 0.0030和p = 0.0123）相关。
每日血糖变异性与肝内脂肪含量、餐后血糖和血浆乳酸浓度相关。
