Henning Michaela, Lindgen Katharina, Paul Desiree, Fuchs Claudia, Niecke Alexander, Albus Christian, Bruns Christiane, Pelzner Kim, Leers Jessica
Department of Psychosomatics and Psychotherapy, University Hospital Cologne, University of Cologne, Cologne, DEU.
Department of Orthopedics, Trauma and Reconstructive Surgery, Sana Hospital Benrath, Düsseldorf, DEU.
Cureus. 2024 Nov 10;16(11):e73391. doi: 10.7759/cureus.73391. eCollection 2024 Nov.
The purpose of this paper is to examine the prevalence and symptom severity of anxiety and depression in patients with gastroesophageal reflux disease (GERD). The correlation between anxiety and depression with the DeMeester score is determined. GERD is a common gastrointestinal disorder that manifests as heartburn, regurgitation, retrosternal pain, cough, and dysphagia. Patients are severely affected by reflux symptoms.
We conducted a prospective cohort study of 458 consecutively enrolled patients who presented to the Department of Functional Upper GI Surgery at the University Hospital of Cologne, Germany. Patients underwent upper gastrointestinal endoscopy, 24-hour pH impedance testing, and high-resolution manometry. We determined the DeMeester score. Psychometric data were collected using the Hospital Anxiety and Depression Scale (HADS).
44.1% (n = 202) of patients had abnormally high HADS anxiety scores and 23.8% (n = 109) had abnormally high HADS depression scores (both >7). Patients without an indication for surgery (51.1%, n = 234) were the most distressed subgroup: 47.9% (n= 112) of these patients had an anxiety score of 8 or higher, and as many as 23.9% (n = 56) of these patients had an anxiety score of 11 or higher. We found a significant effect of elevated anxiety and elevated depression scores on the severity of symptoms such as heartburn and fullness, as well as an effect of elevated anxiety scores on the severity of dysphagia.
Patients with reflux symptoms have a high prevalence of anxiety. Anxiety and partly depression are significantly associated with the severity of reflux symptoms. An adequate multidisciplinary treatment strategy is required.
本文旨在研究胃食管反流病（GERD）患者焦虑和抑郁的患病率及症状严重程度。确定焦虑和抑郁与DeMeester评分之间的相关性。GERD是一种常见的胃肠道疾病，表现为烧心、反流、胸骨后疼痛、咳嗽和吞咽困难。患者受到反流症状的严重影响。
我们对德国科隆大学医院功能性上消化道外科连续收治的458例患者进行了一项前瞻性队列研究。患者接受了上消化道内镜检查、24小时pH阻抗测试和高分辨率测压。我们确定了DeMeester评分。使用医院焦虑抑郁量表（HADS）收集心理测量数据。
44.1%（n = 202）的患者HADS焦虑评分异常高，23.8%（n = 109）的患者HADS抑郁评分异常高（均>7）。无手术指征的患者（51.1%，n = 234）是最痛苦的亚组：这些患者中有47.9%（n = 112）的焦虑评分为8或更高，多达23.9%（n = 56）的患者焦虑评分为11或更高。我们发现焦虑和抑郁评分升高对烧心和饱胀等症状的严重程度有显著影响，焦虑评分升高对吞咽困难的严重程度也有影响。
有反流症状的患者焦虑患病率较高。焦虑以及部分抑郁与反流症状的严重程度显著相关。需要一种适当的多学科治疗策略。
