Kiko Hiroyuki, Asaoka Daisuke, Nomura Osamu, Nomoto Yusuke, Sugano Koji, Matsuno Kei, Homma Yasuhiro, Nishizaki Yuji, Yanagisawa Naotake, Takeda Tsutomu, Abe Daiki, Oki Shotaro, Suzuki Nobuyuki, Akazawa Yoichi, Ueda Kumiko, Ueyama Hiroya, Hojo Mariko, Nagahara Akihito, Isayama Hiroyuki, Miyauchi Katsumi
Department of Gastroenterology, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo 136-0075, Japan.
Department of Respiratory Medicine, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo 136-0075, Japan.
Diagnostics (Basel). 2025 Jun 17;15(12):1537. doi: 10.3390/diagnostics15121537.
To clarify the relationship between constipation and depressive symptoms among the elderly. This single-center, cross-sectional study was performed using baseline data obtained at the time of enrollment in the prospective cohort of the JUSTICE-TOKYO study. Participants underwent assessments including patient profiling, drug use history, the Mini-Mental State Examination (MMSE), the Geriatric Depression Scale 15 (GDS-15), gastrointestinal-related quality of life (QOL), and the constipation scoring system (CSS). Geriatric depressive symptoms were evaluated based on GDS-15. We investigated correlations between GDS-15 scores and various abdominal symptoms and assessed risk factors for geriatric depressive symptoms using multiple regression analysis. A total of 984 elderly participants (57% female, mean age 78.1 ± 6.1 year) were included. The GDS-15 scores were significantly correlated with body mass index (BMI) (r = -0.056) and MMSE (r = -0.092), reflex-related QOL (r = 0.253), pain-related QOL (r = 0.229), fullness-related QOL (r = 0.269), constipation-related QOL (r = 0.329), diarrhea-related QOL (r = 0.264), and CSS (r = 0.285) scores. Multiple regression analysis indicated that BMI (β = -0.069, = 0.020) and MMSE (β = -0.074, = 0.013), constipation-related QOL (β = 0.136, = 0.002), reflex-related QOL (β = 0.126, < 0.001), diarrhea-related QOL (β = 0.095, = 0.006), and CSS (β = 0.098, = 0.016) scores were significantly correlated with GDS-15 scores. Depressive symptoms among older individuals are associated with various abdominal symptoms, particularly constipation. However, the causality between depressive symptoms and constipation cannot be inferred due to the study's cross-sectional design.
为阐明老年人便秘与抑郁症状之间的关系。本单中心横断面研究采用了在JUSTICE - 东京研究前瞻性队列入组时获得的基线数据。参与者接受了包括患者概况、用药史、简易精神状态检查表（MMSE）、老年抑郁量表15项（GDS - 15）、胃肠道相关生活质量（QOL）以及便秘评分系统（CSS）等评估。基于GDS - 15评估老年抑郁症状。我们研究了GDS - 15评分与各种腹部症状之间的相关性，并使用多元回归分析评估老年抑郁症状的危险因素。共纳入984名老年参与者（女性占57%，平均年龄78.1±6.1岁）。GDS - 15评分与体重指数（BMI）（r = -0.056）、MMSE（r = -0.092）、反射相关生活质量（r = 0.253）、疼痛相关生活质量（r = 0.229）、饱胀相关生活质量（r = 0.269）、便秘相关生活质量（r = 0.329）、腹泻相关生活质量（r = 0.264）以及CSS（r = 0.285）评分显著相关。多元回归分析表明，BMI（β = -0.069，P = 0.020）、MMSE（β = -0.074，P = 0.013）、便秘相关生活质量（β = 0.136，P = 0.002）、反射相关生活质量（β = 0.126，P < 0.001）、腹泻相关生活质量（β = 0.095，P = 0.006）以及CSS（β = 0.098，P = 0.016）评分与GDS - 15评分显著相关。老年人的抑郁症状与各种腹部症状相关，尤其是便秘。然而，由于本研究的横断面设计，无法推断抑郁症状与便秘之间的因果关系。
