Sun Di, Hu Baohong, Li Xinna, Yang Ping, Yu Guohua
Department of Pathology, Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Department of Oncology, Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.
Front Oncol. 2024 Nov 26;14:1440119. doi: 10.3389/fonc.2024.1440119. eCollection 2024.
To study and analyze the clinicopathological features of low-grade fumarate hydratase-deficient renal cell carcinoma in order to improve the understanding of the diagnosis and management of rare and specific morphological cases of this tumor.
A case of low-grade FH-deficient renal cell carcinoma in a male is reported, and its clinicopathological features were analyzed and literature review was performed.
A 48-year-old middle-aged male with no relevant positive clinical signs was admitted to the hospital with an incidental finding of a mass in the lower pole of the left kidney during abdominal CT examination. Pathomorphology showed that the tumor cells were arranged in a variety of structures and the cells were low grade eosinophilic. Immunohistochemistry showed Pax-8 (+), Vim (partially +), FH (-), CK7 (-), CD117 (-), P504s (partially +), CD10 (partially +), CA-9 (-), TFE3 (partially +), SDHB (+), CK20 (-), and Ki-67 (+, about 2%). Final pathologic diagnosis: FH-deficient renal cell carcinoma (low grade).
Single pure low-grade FH-deficient renal cell carcinoma of the kidney is extremely rare, and the image structure of this tumor exhibits diverse manifestations, which needs to be differentiated from many renal tumors in clinicopathological diagnosis in order to prevent misdiagnosis.
研究和分析低级别富马酸水合酶缺乏性肾细胞癌的临床病理特征，以提高对该肿瘤罕见且特殊形态病例的诊断和管理的认识。
报告1例男性低级别富马酸水合酶缺乏性肾细胞癌病例，分析其临床病理特征并进行文献复习。
1例48岁中年男性，无相关阳性临床体征，因腹部CT检查偶然发现左肾下极肿块入院。病理形态学显示肿瘤细胞呈多种结构排列，细胞为低级别嗜酸性。免疫组化显示Pax-8（+）、Vim（部分+）、FH（-）、CK7（-）、CD117（-）、P504s（部分+）、CD10（部分+）、CA-9（-）、TFE3（部分+）、SDHB（+）、CK20（-），Ki-67（+，约2%）。最终病理诊断：富马酸水合酶缺乏性肾细胞癌（低级别）。
单纯的低级别肾富马酸水合酶缺乏性肾细胞癌极为罕见，该肿瘤的影像结构表现多样，在临床病理诊断中需与多种肾肿瘤相鉴别，以防止误诊。
