Zhang Yixuan, Tu Lihong, Chen Jian, Zhou Lihong
NMPA Key Laboratory for Monitoring and Evaluation of Cosmetics, Shanghai Innovation R&D, Testing and Evaluation Technical Service Platform of Cosmetics (22DZ2292100), Department of Evaluation of Cosmetics, Shanghai Municipal Center for Disease Control and Prevention, 1380 Zhongshan Rd. W., Changning, Shanghai 200336, China.
Division of Public Health Service and Safety Assessment, Shanghai Institute of Preventive Medicine, 1380 Zhongshan Rd. W., Changning, Shanghai 200336, China.
Int J Endocrinol. 2024 Dec 3;2024:2564389. doi: 10.1155/ije/2564389. eCollection 2024.
Endocrine-disrupting chemicals (EDCs), found in various cosmetic products, interfere with the normal functioning of the endocrine system, impacting hormone regulation and posing risks to human health. Common cosmetic EDCs, such as ultraviolet (UV) filters, parabens, and triclosan, can enter the human body through different routes, including skin absorption. Their presence has been linked to adverse effects on reproduction, immune function, and development. High-throughput in vitro assays, using various human cell lines, were employed to assess the effects of common cosmetic EDCs such as ethylhexyl methoxycinnamate (EHMC), benzophenone-3 (BP-3), homosalate, and parabens. Despite ongoing regulatory efforts, gaps persist in understanding their long-term impacts, particularly when they are present as mixtures or degradation products in the environment. This study focuses on recent in vitro research to investigate the mechanisms through which cosmetic-related EDCs disrupt the endocrine system and other physiological systems. The in vitro findings highlight the broader systemic impact of these chemicals, extending beyond the endocrine system to include immune, reproductive, and cardiovascular effects. This research underscores the importance of developing safer cosmetic formulations and enhancing public health protection, emphasizing the need for stricter regulations.
在各种化妆品中发现的内分泌干扰化学物质（EDC）会干扰内分泌系统的正常功能，影响激素调节并对人类健康构成风险。常见的化妆品EDC，如紫外线（UV）过滤剂、对羟基苯甲酸酯和三氯生，可以通过不同途径进入人体，包括皮肤吸收。它们的存在与对生殖、免疫功能和发育的不良影响有关。使用各种人类细胞系的高通量体外试验被用于评估常见化妆品EDC的影响，如甲氧基肉桂酸乙基己酯（EHMC）、二苯甲酮-3（BP-3）、胡莫柳酯和对羟基苯甲酸酯。尽管监管工作仍在进行，但在了解它们的长期影响方面仍存在差距，特别是当它们以混合物或降解产物的形式存在于环境中时。本研究重点关注近期的体外研究，以调查与化妆品相关的EDC干扰内分泌系统和其他生理系统的机制。体外研究结果突出了这些化学物质更广泛的全身影响，不仅限于内分泌系统，还包括免疫、生殖和心血管方面的影响。这项研究强调了开发更安全的化妆品配方和加强公共卫生保护的重要性，强调了更严格监管的必要性。
