Swaify Islam Y, Hamza Hany, Khattab Ayman M, El-Agha Mohamed-Sameh H, El-Helw Mostafa A, Macky Tamer A, Hassanein Dina H, Salah Shaymaa H, Noureldine Alia M, Fayed Alaa E, Meqdad Yasmine, Al-Etr Salma F, El Qadi Layla, Abdullatif Abdussalam M
Cairo University Ocular Oncology Service, Department of Ophthalmology, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt.
Ocul Oncol Pathol. 2024 Dec;10(4):189-196. doi: 10.1159/000540844. Epub 2024 Aug 27.
We aimed to report the demographic data, clinical features, and management outcomes of patients with uveal melanoma (UM) in a single tertiary center in Egypt.
This is a single-center retrospective case series. Patients with UM who were managed at Cairo University Ocular Oncology Service between January 2019 and December 2023 were included. Records were analyzed for patients' demographics, clinical features and different management options. Outcomes included changes in best corrected visual acuity and tumor dimensions (thickness and largest base diameter), perioperative complications, globe salvage, and recurrence rates.
A total of 93 eyes of 93 patients with UM were treated in our service over a period of 5 years. The mean age of patients was 52.18 ± 13.30 years, and 91.4% of tumors were choroidal or ciliochoroidal. 52 eyes (55.91%) were managed with ruthenium-106 episcleral brachytherapy, of which two eyes required additional brachytherapy, 8 eyes ended with secondary enucleation, and the globe was salvaged in 84.62% of eyes. 8 eyes (8.60%) were managed by gamma knife radiosurgery with or without endoresection. One eye with an iridociliary tumor was managed with partial lamellar sclerouvectomy, and the remaining 32 eyes (34.41%) were primarily enucleated.
Timely referral channels and accurate assessment of cases with UM are invaluable for achievement of higher success rates in tumor regression, as well as globe and/or vision salvage in eyes managed with brachytherapy. Patients with more advanced tumors should be counseled on the importance of more invasive options such as enucleation in achieving lower metastasis and mortality rates.
我们旨在报告埃及一家三级中心葡萄膜黑色素瘤（UM）患者的人口统计学数据、临床特征及治疗结果。
这是一项单中心回顾性病例系列研究。纳入2019年1月至2023年12月在开罗大学眼科肿瘤服务中心接受治疗的UM患者。分析患者的人口统计学数据、临床特征及不同治疗方案。结果包括最佳矫正视力和肿瘤大小（厚度和最大基底直径）的变化、围手术期并发症、眼球保留率及复发率。
在5年期间，我们的服务中心共治疗了93例UM患者的93只眼。患者的平均年龄为52.18±13.30岁，91.4%的肿瘤位于脉络膜或睫状体脉络膜。52只眼（55.91%）接受了钌-106巩膜近距离放疗，其中2只眼需要额外的近距离放疗，8只眼最终接受了二期眼球摘除术，84.62%的眼实现了眼球保留。8只眼（8.60%）接受了伽玛刀放射外科治疗，可联合或不联合内切除。1例虹膜睫状体肿瘤患者接受了部分板层巩膜葡萄膜切除术，其余32只眼（34.41%）主要接受了眼球摘除术。
及时的转诊渠道和对UM病例的准确评估对于提高肿瘤消退成功率以及接受近距离放疗的眼睛的眼球和/或视力保留至关重要。对于肿瘤更为晚期的患者，应告知其眼球摘除等更具侵入性的治疗方案在降低转移率和死亡率方面的重要性。
