Cui Xiangrong, Li Huihui, Huang Xia, Xue Tingting, Wang Shu, Zhu Xinyu, Jing Xuan
Reproductive Medicine Center, The affiliated Children's Hospital of Shanxi Medical University, Children's Hospital of Shanxi, Shanxi Maternal and Child Health Hospital, Taiyuan, China.
Department of Clinical Laboratory, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.
Immun Inflamm Dis. 2024 Dec;12(12):e70089. doi: 10.1002/iid3.70089.
N6-methyladenosine (m6A) modification is a widespread and reversible epigenetic alteration in eukaryotic mRNA, playing a pivotal role in various biological functions. Its significance in female reproductive development and associated diseases has recently become a focal point of research.
This review aims to consolidate current knowledge of the role of m6A modification in female reproductive tissues, emphasizing its regulatory dynamics, functional significance, and implications in reproductive health and disease.
A comprehensive analysis of recent studies focusing on m6A modification in ovarian development, oocyte maturation, embryo development, and the pathogenesis of reproductive diseases.
m6A modification exhibits dynamic regulation in female reproductive tissues, influencing key developmental stages and processes. It plays critical roles in ovarian development, oocyte maturation, and embryo development, underpinning essential aspects of reproductive health. m6A modification is intricately involved in the pathogenesis of several reproductive diseases, including polycystic ovary syndrome (PCOS), premature ovarian failure (POF), and endometriosis, offering insights into potential molecular mechanisms and therapeutic targets.
The review highlights the crucial role of m6A modification in female reproductive development and related diseases. It underscores the need for further research to explore innovative diagnostic and therapeutic strategies for reproductive disorders, leveraging the insights gained from understanding m6A modification's impact on reproductive health.
N6-甲基腺苷（m6A）修饰是真核生物mRNA中一种广泛存在且可逆的表观遗传改变，在多种生物学功能中起关键作用。其在女性生殖发育及相关疾病中的意义最近已成为研究热点。
本综述旨在整合当前关于m6A修饰在女性生殖组织中作用的知识，强调其调控动态、功能意义以及对生殖健康和疾病的影响。
对近期聚焦于m6A修饰在卵巢发育、卵母细胞成熟、胚胎发育及生殖疾病发病机制方面的研究进行全面分析。
m6A修饰在女性生殖组织中表现出动态调控，影响关键发育阶段和过程。它在卵巢发育、卵母细胞成熟和胚胎发育中起关键作用，是生殖健康的重要基础。m6A修饰与包括多囊卵巢综合征（PCOS）、卵巢早衰（POF）和子宫内膜异位症在内的多种生殖疾病的发病机制密切相关，为潜在分子机制和治疗靶点提供了见解。
本综述强调了m6A修饰在女性生殖发育及相关疾病中的关键作用。它强调需要进一步研究，以利用从理解m6A修饰对生殖健康的影响中获得的见解，探索生殖疾病的创新诊断和治疗策略。
