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Kaempferol Exerts Anti-Inflammatory Effects by Accelerating Treg Development via Aryl Hydrocarbon Receptor-Mediated and PU.1/IRF4-Dependent Transactivation of the Aldh1a2/Raldh2 Gene in Dendritic Cells.

作者信息

Takahashi Miki, Nagata Kazuki, Watanuki Yumi, Yamaguchi Masaki, Ishii Kenta, Harada Tomohiro, Minamikawa Natsuki, Katagiri Mayuka, Zhao Weiting, Ito Naoto, Yashiro Takuya, Nishiyama Chiharu

机构信息

Department of Biological Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, Katsushika-ku, Tokyo, Japan.

出版信息

Allergy. 2025 Mar;80(3):896-900. doi: 10.1111/all.16410. Epub 2024 Dec 11.

DOI:10.1111/all.16410
PMID:39660951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11891405/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bd/11891405/b4ceab10e85f/ALL-80-896-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bd/11891405/50c50e60b265/ALL-80-896-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bd/11891405/b4ceab10e85f/ALL-80-896-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bd/11891405/50c50e60b265/ALL-80-896-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33bd/11891405/b4ceab10e85f/ALL-80-896-g001.jpg

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Kaempferol Exerts Anti-Inflammatory Effects by Accelerating Treg Development via Aryl Hydrocarbon Receptor-Mediated and PU.1/IRF4-Dependent Transactivation of the Aldh1a2/Raldh2 Gene in Dendritic Cells.山奈酚通过芳烃受体介导的以及PU.1/IRF4依赖性的醛脱氢酶1A2/视黄醛脱氢酶2基因在树突状细胞中的反式激活加速调节性T细胞发育，从而发挥抗炎作用。
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引用本文的文献

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The Application of Dendritic Cells Vaccines in Tumor Therapy and Their Combination with Biomimetic Nanoparticles.树突状细胞疫苗在肿瘤治疗中的应用及其与仿生纳米颗粒的联合应用
Vaccines (Basel). 2025 Mar 21;13(4):337. doi: 10.3390/vaccines13040337.
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Epigallocatechin-3-Gallate, Quercetin, and Kaempferol for Treatment of Parkinson's Disease Through Prevention of Gut Dysbiosis and Attenuation of Multiple Molecular Mechanisms of Pathogenesis.

本文引用的文献

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Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup.新生儿期通过一种特殊的树突状细胞亚群建立对皮肤共生菌的长期耐受。
Immunity. 2023 Jun 13;56(6):1239-1254.e7. doi: 10.1016/j.immuni.2023.03.008. Epub 2023 Apr 6.
2
Kaempferol Suppresses the Activation of Mast Cells by Modulating the Expression of FcεRI and SHIP1.山奈酚通过调节 FcεRI 和 SHIP1 的表达来抑制肥大细胞的活化。
Int J Mol Sci. 2023 Mar 22;24(6):5997. doi: 10.3390/ijms24065997.
3
The Transcription Factors PU.1 and IRF4 Determine Dendritic Cell-Specific Expression of RALDH2.
表没食子儿茶素-3-没食子酸酯、槲皮素和山奈酚通过预防肠道菌群失调和减轻发病机制的多种分子机制来治疗帕金森病。
Brain Sci. 2025 Jan 31;15(2):144. doi: 10.3390/brainsci15020144.
转录因子 PU.1 和 IRF4 决定 RALDH2 的树突状细胞特异性表达。
J Immunol. 2018 Dec 15;201(12):3677-3682. doi: 10.4049/jimmunol.1800492. Epub 2018 Nov 9.
4
Involvement of heme oxygenase-1 in kaempferol-induced anti-allergic actions in RBL-2H3 cells.
Inflammation. 2009 Apr;32(2):99-108. doi: 10.1007/s10753-009-9108-4.
5
Dendritic cells in intestinal immune regulation.肠道免疫调节中的树突状细胞。
Nat Rev Immunol. 2008 Jun;8(6):435-46. doi: 10.1038/nri2335.
6
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.视黄酸介导的TH17细胞与调节性T细胞的相互分化
Science. 2007 Jul 13;317(5835):256-60. doi: 10.1126/science.1145697. Epub 2007 Jun 14.
7
Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice.柿叶提取物和黄芪苷抑制NC/Nga小鼠的皮炎发展和IgE升高。
J Allergy Clin Immunol. 2000 Jul;106(1 Pt 1):159-66. doi: 10.1067/mai.2000.107194.
8
Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially.膳食黄酮醇槲皮素和山奈酚是芳烃受体的配体，它们对CYP1A1转录有不同影响。
Biochem J. 1999 Jun 15;340 ( Pt 3)(Pt 3):715-22.