Kittel Julie A, Seplaki Christopher L, van Wijngaarden Edwin, Richman Jennifer, Magnuson Allison, Conwell Yeates
Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Blvd, CU 420644, Rochester, NY, 14642, USA.
Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.
Support Care Cancer. 2024 Dec 11;33(1):16. doi: 10.1007/s00520-024-09075-0.
Cancer survivors experience an array of physical, psychological, and social problems after treatment has ended. Perceived social isolation may exacerbate the effects of physical problems on mental health. We examined the association between physical health (cancer-related fatigue and physical function) and mental health (depression and anxiety symptoms) in cancer survivors in the first year of survivorship (i.e., up to one year after the end of treatment with curative intent), as well as the moderating role of perceived social isolation.
Survey data were collected from 118 cancer survivors who completed treatment with curative intent in the last year. We assessed mental and physical health symptoms, as well as perceived social isolation.
In multivariable analyses, fatigue was significantly associated with both depression (β = 0.279, 95% CI: 0.193,0.362) and anxiety symptoms (β = 0.189, 95% CI: 0.106,0.272). Social isolation moderated the effect of fatigue on depression and anxiety such that higher social isolation exacerbated the association of fatigue with mental health.
Cancer survivors who continue to experience fatigue after curative treatment are at risk for mental health problems, including depression and anxiety symptoms. For cancer survivors who feel socially isolated, the association between fatigue and mental health may be stronger. The current standard of care for survivorship does not sufficiently address psychosocial needs. Future research should evaluate the inclusion of social support interventions in early-term survivorship care.
癌症幸存者在治疗结束后会经历一系列身体、心理和社会问题。感知到的社会孤立可能会加剧身体问题对心理健康的影响。我们研究了癌症幸存者在生存第一年（即根治性治疗结束后长达一年）的身体健康（癌症相关疲劳和身体功能）与心理健康（抑郁和焦虑症状）之间的关联，以及感知到的社会孤立的调节作用。
收集了118名去年完成根治性治疗的癌症幸存者的调查数据。我们评估了心理和身体健康症状以及感知到的社会孤立情况。
在多变量分析中，疲劳与抑郁（β = 0.279，95%置信区间：0.193, 0.362）和焦虑症状（β = 0.189，95%置信区间：0.106, 0.272）均显著相关。社会孤立调节了疲劳对抑郁和焦虑的影响，即更高的社会孤立加剧了疲劳与心理健康之间的关联。
根治性治疗后仍持续感到疲劳的癌症幸存者有出现心理健康问题的风险，包括抑郁和焦虑症状。对于感到社会孤立的癌症幸存者，疲劳与心理健康之间的关联可能更强。目前的生存护理标准未能充分满足心理社会需求。未来的研究应评估在早期生存护理中纳入社会支持干预措施的情况。
