Yamada Keiko, Oie Yoshinori, Nishida Nozomi, Maeno Sayo, Kai Chifune, Kitao Masahiro, Kobayashi Reiko, Soma Takeshi, Koh Shizuka, Kawasaki Ryo, Nishida Kohji
Department of Ophthalmology (K.Y., Y.O., N.N., S.M., C.K., M.K., Reiko Kobayashi, T.S., S.K., K.N.), Osaka University Graduate School of Medicine, Suita, Osaka, Japan; and Division of Public Health (Ryo Kawasaki), Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Eye Contact Lens. 2025 Mar 1;51(3):e135-e141. doi: 10.1097/ICL.0000000000001159. Epub 2024 Dec 10.
To assess the quality of life in Japanese patients with Fuchs endothelial corneal dystrophy (FECD) using The National Eye Institute Visual Function Questionnaire.
Here, 34 patients with FECD (FECD group) and 13 healthy individuals (control group) completed the National Eye Institute Visual Function Questionnaire Japanese version by interview format. The association between dominant eye corrected distance visual acuity and composite score (component 11) or subscales in the FECD group was evaluated using Spearman rank correlation coefficient.
The average age was 65.8±11.9 and 60.1±7.9 years in the FECD and control groups, respectively. Corrected distance visual acuity was significantly lower in the FECD group (0.021±0.21 logarithm of the minimum angle of resolution) than in the control group (-0.61±0.055 logarithm of the minimum angle of resolution) ( P <0.0001). Composite scores were significantly lower in the FECD group (77.6±11.0) than in the control group (89.2±7.0) ( P =0.0006). All subscale scores were lower in the FECD group, particularly for distance vision and mental health (81.4±13.1 and 84.0±15.6, respectively) than in the control group (90.7±12.0 and 95.7±5.7) ( P =0.022 and P =0.0046, respectively). Corrected distance visual acuity in the dominant eye did not significantly correlate with composite scores or subscales in the FECD group.
Quality of life is lower in patients with FECD than in healthy individuals, particularly regarding distance vision and mental health.
使用美国国立眼科研究所视觉功能问卷评估日本富克斯内皮性角膜营养不良（FECD）患者的生活质量。
34例FECD患者（FECD组）和13名健康个体（对照组）通过访谈形式完成了美国国立眼科研究所视觉功能问卷日文版。使用Spearman等级相关系数评估FECD组优势眼矫正远视力与综合评分（第11项）或分量表之间的关联。
FECD组和对照组的平均年龄分别为65.8±11.9岁和60.1±7.9岁。FECD组的矫正远视力（最小分辨角对数为0.021±0.21）显著低于对照组（最小分辨角对数为-0.61±0.055）（P<0.0001）。FECD组的综合评分（77.6±11.0）显著低于对照组（89.2±7.0）（P=0.0006）。FECD组所有分量表评分均较低，尤其是远视力和心理健康方面（分别为81.4±13.1和84.0±15.6），低于对照组（90.7±12.0和95.7±5.7）（分别为P=0.022和P=0.0046）。FECD组优势眼的矫正远视力与综合评分或分量表之间无显著相关性。
FECD患者的生活质量低于健康个体，尤其是在远视力和心理健康方面。
