Ternushchak Tetyana M, Tovt-Korshynska Marianna I, Feysa Snizhana V
UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.
Wiad Lek. 2024;77(10):1996-2001. doi: 10.36740/WLek/195167.
Aim: We aimed to assess the prevalence of ID in patients HFpEF and its relation to functional capacity and quality of life.
Materials and Methods: We included in the analysis 121 consecutive outpatients newly diagnosed of HFpEF and tested with iron-related parameters. Patients were subdivided in two groups according to the presence of ID (n = 76, mean age 65.3 ± 7.1 years) or without ID (n =45, mean age 61.6 ± 7.4 years). Physical examination, routine laboratory tests, serum ferritin, transferrin saturation (TSAT), hs CRP, N-terminal proB-type natriuretic peptide (NT-proBNP), standard transthoracic echocardiogram examinations, functional capacity and quality were performed and assessed.
Results: Among all tested patients with iron-related parameters, 63% (76) met the European Society of Cardiology criteria for ID. Additionally, 29% (22) were found to have coexisting anemia. Patients with ID had more pronounced HF symptoms, higher NT-pro-BNP, hs CRP, ferritin and lower TSAT values and more severe diastolic dysfunction. Patients with HFpEF and ID performed worse functional capacity during the 6MWT and had lower quality of life with Minnesota Living with Heart Failure Questionnaire.
Conclusions: ID as one of the most common comorbidities in HFpEF significantly impairs the functional capacity and quality of life.
我们旨在评估射血分数保留的心力衰竭（HFpEF）患者中铁缺乏症（ID）的患病率及其与功能能力和生活质量的关系。
我们纳入分析了121例新诊断为HFpEF的连续门诊患者，并检测了与铁相关的参数。根据是否存在ID将患者分为两组（ID组n = 76，平均年龄65.3±7.1岁；非ID组n = 45，平均年龄61.6±7.4岁）。进行并评估了体格检查、常规实验室检查、血清铁蛋白、转铁蛋白饱和度（TSAT）、高敏C反应蛋白（hs CRP）、N末端B型脑钠肽原（NT-proBNP）、标准经胸超声心动图检查、功能能力和生活质量。
在所有检测了与铁相关参数的患者中，63%（76例）符合欧洲心脏病学会的ID标准。此外，29%（22例）被发现同时存在贫血。ID患者的HF症状更明显，NT-pro-BNP、hs CRP、铁蛋白水平更高，TSAT值更低，舒张功能障碍更严重。HFpEF合并ID的患者在6分钟步行试验（6MWT）中的功能能力较差，使用明尼苏达心力衰竭生活问卷评估的生活质量较低。
ID作为HFpEF最常见的合并症之一，显著损害功能能力和生活质量。
