Chen Bo, Liu Ziyi, Shen Ziyi, Gong Hui, Jiang Yuewei, Su Yingying, Zhou Jinghui, Li Yao
Liaoning Province Key Laboratory of Pulp and Papermaking Engineering, Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials, Liaoning Collaborative Innovation Center for Lignocellulosic Biorefinery, Dalian Polytechnic University, Dalian, Liaoning 116034, P. R. China.
ACS Appl Mater Interfaces. 2024 Dec 25;16(51):70891-70905. doi: 10.1021/acsami.4c17325. Epub 2024 Dec 11.
How to integrate the "soft" (flexibility and self-healing properties) and "hard" (shape retention) into the supramolecular hydrogel system is an attractive challenge. In this work, a supramolecular hydrogel with an energy dissipation structure is designed and prepared for intelligent biomimetic skin. Lignin molecules with disulfide bonds of fracture and healing activities are introduced into the hydrogel system through covalent bonds. A large number of hydrophobic interactions and ionic bonds constitute the cross-linking structure of this supramolecular hydrogel. These supramolecular cross-linking structures endow the hydrogel with "soft" properties with 1200% of elongation at break and 92.5% of self-healing rate. The disulfide bonds between lignin macromolecules give the hydrogel with "hard" properties and can effectively absorb the work of external forces on the supramolecular hydrogel system, thus maintaining the chemical structure, shape, and resistivity. Furthermore, this supramolecular hydrogel shows good biocompatibility, antibacterial properties, tissue fluid removal properties, wound healing promoting properties, and sensing output characteristics. This covalent binding structure of biomass-based macromolecules and disulfide bonds has an important reference value for the design of supramolecular hydrogels with both "hard" and "soft" properties.
如何将“软”（柔韧性和自愈性能）和“硬”（形状保持）特性整合到超分子水凝胶体系中是一个具有吸引力的挑战。在这项工作中，设计并制备了一种具有能量耗散结构的超分子水凝胶用于智能仿生皮肤。通过共价键将具有断裂和愈合活性二硫键的木质素分子引入水凝胶体系。大量的疏水相互作用和离子键构成了这种超分子水凝胶的交联结构。这些超分子交联结构赋予水凝胶“软”特性，其断裂伸长率为1200%，自愈率为92.5%。木质素大分子之间的二硫键赋予水凝胶“硬”特性，并能有效吸收外力对超分子水凝胶体系的作用，从而保持化学结构、形状和电阻率。此外，这种超分子水凝胶表现出良好的生物相容性、抗菌性能、组织液清除性能、促进伤口愈合性能和传感输出特性。这种基于生物质大分子的共价结合结构和二硫键对于设计兼具“硬”和“软”特性的超分子水凝胶具有重要的参考价值。
