Lloyd Melanie, Bassi Divya, Zomer Ella, Ademi Zanfina
Health Economics and Policy Evaluation Research (HEPER), Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia.
School of Public Health and Preventative Medicine, Monash University, Melbourne, Australia.
Cancer Epidemiol. 2025 Feb;94:102726. doi: 10.1016/j.canep.2024.102726. Epub 2024 Dec 10.
Breast cancer exerts a considerable burden on an individual's health, but also impacts society more broadly through lost work productivity. This study aimed to measure the quality of life and productivity burden among Australian females of working age diagnosed with breast cancer in 2022.
A Markov lifetable model was simulated twice; the initial simulation followed the progression of Australian females diagnosed with breast cancer in 2022 using current population incidence rates, whilst the second simulation hypothetically assumed there were no females living with breast cancer. The difference in the number of life years lived, quality-adjusted life years (QALYs) and productivity-adjusted life years (PALYs) between the two simulations was estimated. All model inputs were derived from previously published sources. Financial costs attributable to each PALY were estimated utilising the total gross domestic product (GDP) for each equivalent full-time worker in Australia (2022 prices) and in scenario analysis using the human capital approach in terms of wage loss, with discounting of 5 % applied.
Over a ten-year period from 2022 to 2031, it is predicted that breast cancer will result in the loss of 4286 years of life lived and 15,597 QALYs. It is also predicted that 16,403 PALYs will be lost, equating to AU$3.26 billion in lost GDP. Results remain robust, showing limited sensitivity to changes in the inputs.
Breast cancer significantly impacts the health and economic welfare of Australian females of working age. Funding initiatives and programs which accelerate recovery and integration back into the workforce are likely to be economically beneficial.
乳腺癌给个人健康带来相当大的负担，同时也通过工作生产力的损失对社会产生更广泛的影响。本研究旨在衡量2022年被诊断患有乳腺癌的澳大利亚工作年龄女性的生活质量和生产力负担。
对马尔可夫生命表模型进行了两次模拟；第一次模拟根据当前人口发病率跟踪2022年被诊断患有乳腺癌的澳大利亚女性的病情进展，而第二次模拟则假设没有患乳腺癌的女性。估计了两次模拟之间在生存年数、质量调整生命年（QALY）和生产力调整生命年（PALY）方面的差异。所有模型输入均来自先前发表的资料。利用澳大利亚每个全职等效工人的国内生产总值（GDP）总额（2022年价格），并在情景分析中采用人力资本方法计算工资损失，估计了每个PALY的财务成本，并应用了5%的贴现率。
预计在2022年至2031年的十年期间，乳腺癌将导致4286个生命年的损失和15597个质量调整生命年的损失。预计还将损失16403个生产力调整生命年，相当于32.6亿澳元的GDP损失。结果仍然稳健，对输入变化的敏感性有限。
乳腺癌对澳大利亚工作年龄女性的健康和经济福利有重大影响。资助加速康复并使其重新融入劳动力队伍的倡议和项目可能在经济上是有益的。
