De Ley G, Nshimyumuremyi J B, Leusen I
Stroke. 1985 Jan-Feb;16(1):69-73. doi: 10.1161/01.str.16.1.69.
Acute occlusion of one common carotid artery in the anesthetized normocapnic rat results in a moderate cerebral blood flow (CBF) decrease in both cerebral hemispheres. No asymmetrical perfusion is observed when the overall flow in each hemisphere is considered. The increase in blood flow which normally occurs in hypercapnia is strongly impaired in the cerebral hemisphere on the occluded side resulting in an important asymmetrical hemispheric perfusion. The days (1, 5, 15, 30) following unilateral carotid occlusion normal control CBF values are found in both hemispheres in normocapnic conditions. Hemispheric perfusion asymmetry in hypercapnia also becomes progressively less pronounced with time but a slight asymmetry still persists one month after unilateral carotid occlusion.
在麻醉状态下的正常碳酸血症大鼠中，一侧颈总动脉急性闭塞会导致两个脑半球的脑血流量（CBF）适度下降。当考虑每个半球的总体血流量时，未观察到不对称灌注。正常情况下在高碳酸血症时出现的血流量增加在闭塞侧的脑半球中受到严重损害，导致重要的不对称半球灌注。在单侧颈动脉闭塞后的第1天、5天、15天、30天，在正常碳酸血症条件下，两个半球均发现正常对照CBF值。高碳酸血症时的半球灌注不对称也会随着时间的推移而逐渐变得不那么明显，但在单侧颈动脉闭塞后一个月仍存在轻微的不对称。
