力量训练对降低人类免疫缺陷病毒感染者骨折风险的影响。

Impact of strength training on reducing risk of fractures in people living with Human Immunodeficiency virus.

作者信息

Roberto Dos Santos Wlaldemir, Romário Dos Santos Walmir, Paes Pedro Pinheiro, Fernandes Talita Morais, Morais Fernades Ana Paula

机构信息

School of Nursing of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; School of Physical Education, University of Pernambuco, Recife, Brazil.

School of Physical Education and Sport of Ribeirão Preto, University of Ribeirão Preto, Ribeirão Preto, Brazil.

出版信息

J Bodyw Mov Ther. 2025 Mar;41:13-20. doi: 10.1016/j.jbmt.2024.11.012. Epub 2024 Nov 9.

DOI:10.1016/j.jbmt.2024.11.012

PMID:39663078

Abstract

BACKGROUND

The progression of HIV and prolonged antiretroviral therapy (ART) lead to secondary changes in patients, such as reduced bone mineral density (BMD), which increases the susceptibility to fractures and, consequently, the associated morbidity and mortality.

PURPOSE

The study aimed to assess the impact of strength training on the risk of fractures in people living with Human Immunodeficiency Virus (PLHIV).

METHODS

Sixteen HIV-positive men with lipodystrophy syndrome, under ART, aged 40-70 years, inactive for three months, were included. They underwent 12 weeks of strength training (36 sessions) and were evaluated before and after for fracture risk and femoral neck BMD using FRAX (Fracture Risk Assessment) and DXA (Dual-energy X-ray Absorptiometry), respectively, along with body composition. Comparative statistical analyses were conducted.

RESULTS

The results showed a reduction in the risk of major fractures by 24.79% (p = 0.009) and of femoral neck fractures by 72.85% (p = 0.004). There was a significant increase in femoral neck BMD by 11.69% (p = 0.001) and in the T-score by 7.94% (p = 0.002), inversely correlating with fracture risk. Total muscle mass increased by 3.79% (p = 0.011) and lower limb bone mass by 3.55% (p = 0.028), positively correlating with BMD and T-score.

CONCLUSION

It was concluded that a short period of training (12 weeks) reduced the risk of fractures in PLHIV. However, further research is needed to support evidence-based clinical practices.

摘要

背景

HIV的进展和长期抗逆转录病毒疗法（ART）会导致患者出现继发性变化，如骨矿物质密度（BMD）降低，这会增加骨折易感性，进而增加相关的发病率和死亡率。

目的

本研究旨在评估力量训练对人类免疫缺陷病毒（HIV）感染者骨折风险的影响。

方法

纳入16名年龄在40 - 70岁、患有脂肪代谢障碍综合征、正在接受ART治疗且已三个月未进行活动的HIV阳性男性。他们接受了12周的力量训练（36节课程），并分别在训练前后使用FRAX（骨折风险评估）和DXA（双能X线吸收法）评估骨折风险和股骨颈BMD，同时评估身体成分。进行了比较性统计分析。

结果

结果显示，主要骨折风险降低了24.79%（p = 0.009），股骨颈骨折风险降低了72.85%（p = 0.004）。股骨颈BMD显著增加了11.69%（p = 0.001），T值增加了7.94%（p = 0.002），与骨折风险呈负相关。总肌肉量增加了3.79%（p = 0.011），下肢骨量增加了3.55%（p = 0.028），与BMD和T值呈正相关。