Cokkinos D V, DePuey E G, Rivas A H, de Castro C M, Burdine J A, Leachman R D, Hall R J
Am Heart J. 1985 Jan;109(1):104-12. doi: 10.1016/0002-8703(85)90423-5.
Systolic time intervals (STI) were correlated with radionuclide angiography studies (RAS) in 57 patients at rest, during maximal semisitting bicycle exercise, and at 4 minutes following the cessation of exercise. Eleven were judged as being free of coronary artery disease (group 1), while 14 had coronary artery disease without (group 2A), and 27 (group 2B) with a previous transmural myocardial infarction. For RAS, resting radionuclide ejection fraction (REF), the changes in REF and end-systolic volume, and the development of a wall motion abnormality at peak exercise were each highly correlated with the presence of coronary disease (p less than 0.001). The accuracy of STI parameters in predicting the presence of coronary disease was poor (less than 60%). Changes in end-diastolic volume (EDV) correlated significantly with PEP/LVET and LVET1 changes following exercise. Moreover, patients with an abnormal (greater than 25%) increase in EDV at peak exercise had a greater increase in LVET1 in the postexercise period (p less than 0.01). We conclude that STI is not accurate enough a predictor of coronary disease or left ventricular function to serve as a useful screening test. Changes in STI parameters appear to be more related to changes in ventricular volume than to ventricular function.
对57例患者在静息状态、最大半卧位自行车运动期间及运动停止后4分钟时的收缩期时间间期（STI）与放射性核素血管造影研究（RAS）进行了相关性分析。11例被判定无冠状动脉疾病（第1组），14例有冠状动脉疾病但无（第2A组），27例（第2B组）有既往透壁性心肌梗死。对于RAS，静息放射性核素射血分数（REF）、REF和收缩末期容积的变化以及运动峰值时室壁运动异常的出现均与冠状动脉疾病的存在高度相关（p<0.001）。STI参数预测冠状动脉疾病存在的准确性较差（<60%）。舒张末期容积（EDV）的变化与运动后PEP/LVET和LVET1的变化显著相关。此外，运动峰值时EDV异常增加（>25%）的患者在运动后LVET1的增加更大（p<0.01）。我们得出结论，STI作为冠状动脉疾病或左心室功能的预测指标不够准确，不能作为一项有用的筛查试验。STI参数的变化似乎与心室容积的变化比与心室功能的变化更相关。
