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本文引用的文献

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Stepwise Add-On and Endotype-informed Targeted Combination Therapy to Treat Obstructive Sleep Apnea: A Proof-of-Concept Study.序贯添加和表型指导的靶向联合治疗阻塞性睡眠呼吸暂停：概念验证研究。
Ann Am Thorac Soc. 2023 Sep;20(9):1316-1325. doi: 10.1513/AnnalsATS.202210-892OC.
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One Month Dosing of Atomoxetine plus Oxybutynin in Obstructive Sleep Apnea: A Randomized, Placebo-controlled Trial.托莫西汀加奥昔布宁治疗阻塞性睡眠呼吸暂停一个月的剂量：一项随机、安慰剂对照试验。
Ann Am Thorac Soc. 2023 Apr;20(4):584-595. doi: 10.1513/AnnalsATS.202206-492OC.
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The norepinephrine reuptake inhibitor reboxetine alone reduces obstructive sleep apnea severity: a double-blind, placebo-controlled, randomized crossover trial.去甲肾上腺素再摄取抑制剂瑞波西汀单独使用可降低阻塞性睡眠呼吸暂停严重程度：一项双盲、安慰剂对照、随机交叉试验。
J Clin Sleep Med. 2023 Jan 1;19(1):85-96. doi: 10.5664/jcsm.10256.
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A Randomized Controlled Clinical Trial Exploring Safety and Tolerability of Sulthiame in Sleep Apnea.随机对照临床试验探索噻加宾治疗睡眠呼吸暂停的安全性和耐受性。
Am J Respir Crit Care Med. 2022 Jun 15;205(12):1461-1469. doi: 10.1164/rccm.202109-2043OC.
5
Reboxetine Plus Oxybutynin for OSA Treatment: A 1-Week, Randomized, Placebo-Controlled, Double-Blind Crossover Trial.雷贝拉唑加奥昔布宁治疗阻塞性睡眠呼吸暂停：一项为期 1 周、随机、安慰剂对照、双盲交叉试验。
Chest. 2022 Jan;161(1):237-247. doi: 10.1016/j.chest.2021.08.080. Epub 2021 Sep 20.
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7
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Is sleep apnea an independent risk factor for prevalent and incident diabetes in the Busselton Health Study?在巴瑟尔顿健康研究中，睡眠呼吸暂停是糖尿病流行和发病的独立危险因素吗？
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图像：持续气道正压通气联合托莫西汀-奥昔布宁治疗重度阻塞性睡眠呼吸暂停

Images: Combined positive air way pressure and atomoxetine-oxybutynin for the treatment of severe obstructive sleep apnea.

作者信息

Mitton Jonathan, Khan Muhammad E, Combs Daniel, Parthasarathy Sairam, Mashaqi Saif

机构信息

Department of Pediatrics, The University of Arizona College of Medicine - Tucson, Tucson, Arizona.

Department of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The University of Arizona College of Medicine - Tucson, Tucson, Arizona.

出版信息

J Clin Sleep Med. 2025 Apr 1;21(4):743-746. doi: 10.5664/jcsm.11496.

DOI:10.5664/jcsm.11496
PMID:39663915
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11965088/
Abstract

UNLABELLED

Obstructive sleep apnea is one of the most common sleep disorders. Positive airway pressure therapy is considered the gold standard for treating obstructive sleep apnea. Yet, optimal therapy might not be achieved in some cases of severe obstructive sleep apnea, despite using maximum settings. In this case report, we describe the successful combination of positive airway pressure therapy and atomoxetine-oxybutynin in reducing the apnea-hypopnea index from the severe range to the mild to moderate range. This was also associated with significant improvement in several symptoms including excessive daytime sleepiness and drowsiness while driving.

CITATION

Mitton J, Khan ME, Combs D, Parthasarathy S, Mashaqi S. Images: combined positive air way pressure and atomoxetine-oxybutynin for the treatment of severe obstructive sleep apnea. . 2025;21(4):743-746.

摘要

未标注

阻塞性睡眠呼吸暂停是最常见的睡眠障碍之一。气道正压通气治疗被认为是治疗阻塞性睡眠呼吸暂停的金标准。然而，在一些严重阻塞性睡眠呼吸暂停病例中，尽管使用了最大设置，仍可能无法实现最佳治疗效果。在本病例报告中，我们描述了气道正压通气治疗与托莫西汀 - 奥昔布宁联合使用成功地将呼吸暂停低通气指数从严重范围降至轻度至中度范围。这也与包括白天过度嗜睡和驾驶时困倦在内的多种症状的显著改善相关。

引用

米顿 J、汗 ME、库姆斯 D、帕萨拉蒂 S、马沙基 S。图片：气道正压通气与托莫西汀 - 奥昔布宁联合治疗严重阻塞性睡眠呼吸暂停。. 2025；21(4)：743 - 746。