Gupta Siddharth, Priyadarshi Akash, Beg Mujahid, Rabbani M U
Department of Medicine, Jawaharlal Nehru Medical College & Hospital, Aligarh Muslim University, Aligarh, IND.
Department of Cardiology, Jawaharlal Nehru Medical College & Hospital, Aligarh Muslim University, Aligarh, IND.
Cureus. 2024 Nov 11;16(11):e73454. doi: 10.7759/cureus.73454. eCollection 2024 Nov.
Objective In this study, we aimed to analyze the correlation between lipid profile and angiographic profile in terms of vessel involvement, segment involvement, and angiographic severity in patients with acute coronary syndrome (ACS). Methods One hundred patients diagnosed with ACS for the first time and undergoing coronary catheterization were included. Fasting samples for lipids profile were obtained. Data were analyzed to determine if lipid parameters were related to the severity of coronary artery disease (CAD), as measured by the SYNTAX score, and the number and location of affected vessels. The SYNTAX score offers a robust and reliable method for assessing the severity of CAD. By providing a comprehensive and quantitative evaluation, it empowers clinicians to make informed decisions about patient management and optimize treatment outcomes. Results Total cholesterol (TC), non-high-density lipoprotein (non-HDL) cholesterol, and apolipoprotein (Apo) B/A ratio correlated positively with the number of vessels involved, i.e., single, double, or triple vessel disease (SVD, DVD, and TVD). Apo B/A also showed a significant relationship with left anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA) involvement. RCA involvement had a significant association with TC and non-HDL levels. TC, non-HDL, and Apo B/A showed a significant relationship with mid-segment involvement. Apo A1 was found to have a significant inverse correlation, while Apo B, Apo B/A, and TC/HDL had a significant positive correlation with SYNTAX score class severity. Conclusions Our study revealed a strong association between lipid parameters and CAD severity, particularly in terms of vessel involvement and SYNTAX score. Elevated levels of TC, non-HDL cholesterol, and Apo B/A were linked to more extensive disease.
目的 在本研究中，我们旨在分析急性冠状动脉综合征（ACS）患者的血脂谱与血管造影特征在血管受累、节段受累及血管造影严重程度方面的相关性。方法 纳入首次诊断为ACS并接受冠状动脉造影的100例患者。采集空腹血脂样本。分析数据以确定血脂参数是否与通过SYNTAX评分衡量的冠状动脉疾病（CAD）严重程度以及受累血管的数量和位置相关。SYNTAX评分提供了一种评估CAD严重程度的可靠方法。通过提供全面和定量的评估，它使临床医生能够就患者管理做出明智决策并优化治疗结果。结果 总胆固醇（TC）、非高密度脂蛋白（non-HDL）胆固醇和载脂蛋白（Apo）B/A比值与受累血管数量呈正相关，即单支、双支或三支血管病变（SVD、DVD和TVD）。Apo B/A也与左前降支（LAD）、左旋支（LCX）和右冠状动脉（RCA）受累显著相关。RCA受累与TC和non-HDL水平显著相关。TC、non-HDL和Apo B/A与中段受累显著相关。发现Apo A1呈显著负相关，而Apo B、Apo B/A和TC/HDL与SYNTAX评分分级严重程度呈显著正相关。结论 我们的研究揭示了血脂参数与CAD严重程度之间存在密切关联，特别是在血管受累和SYNTAX评分方面。TC、non-HDL胆固醇和Apo B/A水平升高与更广泛的疾病相关。
