单次/多次经皮注射LR-PRP可提高骨折延迟愈合的骨愈合率：一项前瞻性病例系列研究
Single/ Multiple Dose Percutaneously Injected LR-PRP Enhances Union Rate in Fracture Delayed Unions: A Prospective Case Series.
作者信息
Kunal Kishor, Gahlot Nitesh, Choudhary Neeraj, Elhence Abhay
机构信息
Department of Orthopedics, AIIMS, Jodhpur, Rajasthan 342005 India.
出版信息
Indian J Orthop. 2024 Sep 10;58(12):1827-1832. doi: 10.1007/s43465-024-01265-6. eCollection 2024 Dec.
BACKGROUND
Average bone healing times of common fractures in adults ranges from 3 to 12 weeks and is location dependent. Platelet Rich Plasma (PRP) stimulates natural healing process through growth factors contained in platelets and has been employed for the same in delayed unions.
METHODS
All patients > 18 years and documented delayed union were included in the study. Patients were followed up monthly after each Leucocyte-rich PRP (LR-PRP) injection and a decision for repeat PRP injection was taken on basis of visible impression in radiograph after previous injection.
RESULTS
Total 36 patients were studied in which 5 patients were lost to follow-up. Union was achieved in 28/31 (90.3%). 20 (71.4%) patients required only single PRP injections. 4 (14.3%) patients required 2 PRP injections, 3 (10.7%) patients required 3 PRP injections and 1 (3.6%) patient required 4 PRP injection. There was no significant correlation of number of PRPs to time from 1st PRP-union or time from last PPR- union.
CONCLUSION
Single/multiple dose percutaneously administered LR-PRP can be used as a fruitful alternative to catalyze union in patients having delayed union irrespective of site of injury.
背景
成人常见骨折的平均愈合时间为3至12周，且因骨折部位而异。富血小板血浆（PRP）通过血小板中所含的生长因子刺激自然愈合过程，并已用于治疗延迟愈合。
方法
纳入所有年龄大于18岁且有延迟愈合记录的患者。每次注射富白细胞PRP（LR-PRP）后每月对患者进行随访，并根据上次注射后X线片上的明显表现决定是否重复注射PRP。
结果
共研究了36例患者，其中5例失访。31例患者中有28例（90.3%）实现了骨折愈合。20例（71.4%）患者仅需单次注射PRP。4例（14.3%）患者需注射2次PRP，3例（10.7%）患者需注射3次PRP，1例（3.6%）患者需注射4次PRP。PRP注射次数与首次PRP注射至骨折愈合的时间或最后一次PRP注射至骨折愈合的时间之间无显著相关性。
结论
无论损伤部位如何，经皮注射单剂量/多剂量LR-PRP可作为促进延迟愈合患者骨折愈合的有效替代方法。
Zotero 插件