Chang Suk Won, Jeong Yeonsu, Kang Ju Wan, Kim Chang-Hoon, Cho Hyung-Ju
Department of Otorhinolaryngology, Jeju National University Hospital, Jeju National University College of Medicine, Jeju, Republic of Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Republic of Korea.
J Rhinol. 2024 Jul;31(2):101-105. doi: 10.18787/jr.2024.00020. Epub 2024 Jul 31.
The serum galactomannan test (GM test) and the (1,3)-β-D-glucan test (G test) are utilized in diagnosing invasive fungal sinusitis. However, their effectiveness in detecting paranasal sinus fungus balls (FBs) has not been established. This study aimed to explore their diagnostic value in patients with FBs.
We retrospectively reviewed the medical records of 105 patients (42 with FBs and 63 with chronic rhinosinusitis [CRS]) who underwent serum GM and G tests between June 2020 and May 2021. Olfactory test results and demographics were also analyzed.
There were 42 FB patients (10 men, 32 women) and 63 CRS patients (27 men, 36 women). The positivity rates for serum GM (7.1% in the FB group vs. 3.2% in the CRS group, p=0.640) and G test (9.5% in the FB group vs. 11.1% in the CRS group, p=0.482) did not differ significantly between groups. The sensitivities of the GM and G tests were 7.1% and 9.5%, respectively, and their specificities were 96.8% and 88.9%, respectively. The positive predictive values were 60.0% for the GM test and 36.3% for the G test, and the negative predictive values were 61.0% for the GM test and 59.6% for the G test.
Serum GM and G tests demonstrated low sensitivity and high specificity, indicating limited effectiveness in differentiating between patients with FBs and those with CRS. Histological examination remains the gold standard for the definitive diagnosis of FBs.
血清半乳甘露聚糖检测（GM检测）和（1,3）-β-D-葡聚糖检测（G检测）用于诊断侵袭性真菌性鼻窦炎。然而，它们在检测鼻窦真菌球（FBs）方面的有效性尚未确定。本研究旨在探讨其在FBs患者中的诊断价值。
我们回顾性分析了2020年6月至2021年5月期间接受血清GM和G检测的105例患者（42例FBs患者和63例慢性鼻-鼻窦炎[CRS]患者）的病历。还分析了嗅觉测试结果和人口统计学数据。
FBs患者42例（男性10例，女性32例），CRS患者63例（男性27例，女性36例）。血清GM检测的阳性率（FBs组为7.1%，CRS组为3.2%，p = 0.640）和G检测的阳性率（FBs组为9.5%，CRS组为11.1%，p = 0.482）在两组之间无显著差异。GM检测和G检测的敏感性分别为7.1%和9.5%，特异性分别为96.8%和88.9%。GM检测的阳性预测值为60.0%，G检测的阳性预测值为36.3%，GM检测的阴性预测值为61.0%，G检测的阴性预测值为59.6%。
血清GM和G检测显示出低敏感性和高特异性，表明在区分FBs患者和CRS患者方面有效性有限。组织学检查仍然是FBs确诊的金标准。
